期刊
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
卷 576, 期 -, 页码 53-58出版社
ACADEMIC PRESS INC ELSEVIER SCIENCE
DOI: 10.1016/j.bbrc.2021.08.093
关键词
Cold atmospheric plasma; Chitin polymer; Reactive oxygen species; Molecular dynamics
资金
- National Natural Science Foundation of China [52077128]
Reactive molecular dynamics simulations were used to investigate the interactions between oxygen plasma species and chitin polymer, revealing that O and OH species can break important structural bonds of chitin and affect the inactivation mechanism of Candida albicans.
Cold atmospheric plasma (CAP) has attracted significant attention and has been widely used to inactivate pathogens based on its excellent effect; however, the mechanisms underlying the interactions between plasma-generated species and organisms have not yet been fully elucidated. In this paper, the interactions of reactive oxygen plasma species (O, OH and H2O2) with chitin polymer (the skeletal component of the Candida albicans cell wall) were investigated by means of reactive molecular dynamics simulations from a microscopic point of view. Our simulations show that O and OH species can break important structural bonds (e.g., N-H bonds, O-H bonds and C-H bonds) of chitin. This is followed by a cascade of bond cleavage and double bond formation events. This simulation study aimed to improve the understanding of the micromechanism of plasma-inactivated Candida albicans at the atomic level. (C) 2021 Elsevier Inc. All rights reserved.
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