Diacerein attenuates vascular dysfunction by reducing inflammatory response and insulin resistance in type 2 diabetic rats

Aim: To examine the effect of diacerein on vascular dysfunction in type 2 diabetic rats and elucidate the mechanism of diacerein. Methods: In a rat model, type 2 diabetes was induced by high-fat diet and streptozotocin. Vascular function was assessed in vascular reactivity experiment. The effect of diacerein (10 or 20 mg/kg/day) on blood glucose, inflammation and insulin signaling, and modulators in vascular tissue in diabetic rats were investigated by molecular and biochemical approaches. Results: In this study, diacerein inhibited diabetes-induced vascular dysfunction. Diacerein treatment normalized blood glucose, insulin tolerance test, inflammatory cytokine levels and nitric oxide synthases expression in diabetic rats. Moreover, diacerein inhibited NF-KB and NLRP3 pathways and activated in-sulin signaling pathway related proteins IRS-1 and AKT in diabetic rats. Conclusion: Diacerein improved vascular function effectively in diabetic rats by suppressing inflamma-tion and reducing insulin resistance. These results suggest that diacerein may represent a novel therapy for patients with diabetes. (c) 2021 Elsevier Inc. All rights reserved.

Automated summary

Diacerein effectively improves vascular function in diabetic rats by suppressing inflammation and reducing insulin resistance, suggesting its potential as a novel therapy for patients with diabetes.