4.0 Article

It is time to shift the treatment paradigm in myelodysplastic syndromes: A focus on novel developments and current investigational approaches exploring combinatorial therapy in high-risk MDS

相关参考文献

注意:仅列出部分参考文献,下载原文获取全部文献信息。
Article Oncology

Eprenetapopt (APR-246) and Azacitidine in TP53-Mutant Myelodysplastic Syndromes

David A. Sallman et al.

Summary: The combination treatment with eprenetapopt and azacitidine is well-tolerated and results in high rates of clinical response and molecular remissions in patients with TP53-mutant MDS and oligoblastic AML.

JOURNAL OF CLINICAL ONCOLOGY (2021)

Article Oncology

Eprenetapopt Plus Azacitidine in TP53-Mutated Myelodysplastic Syndromes and Acute Myeloid Leukemia: A Phase II Study by the Groupe Francophone des Myelodysplasies (GFM)

Thomas Cluzeau et al.

Summary: The combination of Eprenetapopt with AZA showed potentially higher overall response rate (ORR) and complete remission (CR) rate, as well as longer overall survival (OS) in untreated high-risk TP53m MDS and AML patients, with main treatment-related adverse events being febrile neutropenia and neurologic adverse events.

JOURNAL OF CLINICAL ONCOLOGY (2021)

Review Oncology

Tim-3 finds its place in the cancer immunotherapy landscape

Nandini Acharya et al.

JOURNAL FOR IMMUNOTHERAPY OF CANCER (2020)

Article Medicine, General & Internal

Azacitidine and Venetoclax in Previously Untreated Acute Myeloid Leukemia

C. D. DiNardo et al.

NEW ENGLAND JOURNAL OF MEDICINE (2020)

Review Immunology

TIM3 comes of age as an inhibitory receptor

Yochai Wolf et al.

NATURE REVIEWS IMMUNOLOGY (2020)

Review Oncology

Second- and third-generation drugs for immuno-oncology treatment-The more the better?

Wolfram C. M. Dempke et al.

EUROPEAN JOURNAL OF CANCER (2017)

Article Medicine, General & Internal

TP53 and Decitabine in Acute Myeloid Leukemia and Myelodysplastic Syndromes

J. S. Welch et al.

NEW ENGLAND JOURNAL OF MEDICINE (2016)

Review Cell Biology

Function and regulation of Cullin-RING ubiquitin ligases

MD Petroski et al.

NATURE REVIEWS MOLECULAR CELL BIOLOGY (2005)

Article Biochemistry & Molecular Biology

An intact NEDD8 pathway is required for Cullin-dependent ubiquitylation in mammalian cells

M Ohh et al.

EMBO REPORTS (2002)

Article Multidisciplinary Sciences

A Nedd8 conjugation pathway is essential for proteolytic targeting of p27Kip1 by ubiquitination

VN Podust et al.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2000)

Article Biochemistry & Molecular Biology

Nedd8 modification of Cul-1 activates SCFβTrCp-dependent ubiquitination of IκBα

MA Read et al.

MOLECULAR AND CELLULAR BIOLOGY (2000)