Therapeutic effects of androgens for cachexia

Cachexia is a complex wasting syndrome, accompanying a variety of end-stage chronic diseases, such as cancer, heart failure and human immunodeficiency virus (HIV) infection/acquired immunodeficiency syndrome (AIDS). It significantly affects patients' quality of life and survival. Multiple therapeutic approaches have been studied over time. However, despite promising results, no drug has been approved to date. In this review, we examine and discuss the available data on the therapeutic effects of androgens and selective androgen receptor modulators (SARMs) for cachexia.(c) 2021 Elsevier Ltd. All rights reserved.

Automated summary

This review examines the available data on the therapeutic effects of androgens and selective androgen receptor modulators (SARMs) for cachexia, a complex wasting syndrome associated with various end-stage chronic diseases. Despite promising results, no approved drug has been found to date.