期刊
BEST PRACTICE & RESEARCH CLINICAL ENDOCRINOLOGY & METABOLISM
卷 36, 期 5, 页码 -出版社
ELSEVIER SCI LTD
DOI: 10.1016/j.beem.2021.101598
关键词
cachexia; muscle wasting; HIV; androgens; testosterone; selective androgen receptor modulators
This review examines the available data on the therapeutic effects of androgens and selective androgen receptor modulators (SARMs) for cachexia, a complex wasting syndrome associated with various end-stage chronic diseases. Despite promising results, no approved drug has been found to date.
Cachexia is a complex wasting syndrome, accompanying a variety of end-stage chronic diseases, such as cancer, heart failure and human immunodeficiency virus (HIV) infection/acquired immunodeficiency syndrome (AIDS). It significantly affects patients' quality of life and survival. Multiple therapeutic approaches have been studied over time. However, despite promising results, no drug has been approved to date. In this review, we examine and discuss the available data on the therapeutic effects of androgens and selective androgen receptor modulators (SARMs) for cachexia.(c) 2021 Elsevier Ltd. All rights reserved.
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