Resting state predicts neural activity during reward-guided decision making: An fMRI study on Balloon Analogue Risk Task

In our previous work [8], we have shown that resting state (RS) functional connectivity metrics are significantly related with behavioural performance at Balloon Analogue Risk Task (BART). In the present study we investi-gated the hypothesis of an association between RS metrics and neural activity evoked by BART execution. A group-level whole-brain regression was run to assess whether RS metrics predict brain activation during the BART, in a sample of 35 young healthy adults (mean age 23 +/- 2 years, 25 F). Results complete the previous findings showing that RS is also significantly associated with the neural activity during BART execution. Spe-cifically, ALFF is positively associated with the activity of both the right inferior parietal lobule and the left caudate. These new results are coherent with previous evidence indicating RS abnormalities in clinical conditions characterised by symptoms of impulse control disorders, and further suggest that RS might be a stable predictor of both behavioural indices and neural correlates of impulsivity and of reward-guided decision-making.

Automated summary

The study revealed a significant association between resting state functional connectivity metrics and neural activity during Balloon Analogue Risk Task (BART) execution, suggesting that resting state might be a stable predictor of both behavioral indices and neural correlates of impulsivity and reward-guided decision-making.