4.2 Article

A Polygenic Approach to Understanding Resilience to Peer Victimisation

期刊

BEHAVIOR GENETICS
卷 52, 期 1, 页码 1-12

出版社

SPRINGER
DOI: 10.1007/s10519-021-10085-5

关键词

Polygenic scores; Victimisation; Resilience; Depression; Wellbeing; ALSPAC

资金

  1. UK Medical Research Council [217065/Z/19/Z]
  2. Wellcome [217065/Z/19/Z]
  3. Elizabeth Blackwell Institute for Health Research, University of Bristol
  4. Wellcome Trust Institutional Strategic Support Fund [105612/Z/14/Z]
  5. Philip Leverhulme Prize
  6. Alan Turing Institute under the EPSRC [EP/N510129/1]
  7. Economic and Social Research Council (ESRC) [ES/T007370/1]
  8. MRC Integrative Epidemiology Unit at the University of Bristol [MC_UU_00011/7]
  9. National Institute for Health Research (NIHR) Biomedical Research Centre at the University Hospitals Bristol NHS Foundation Trust
  10. University of Bristol [BRC-1215-2011]
  11. EPSRC [EP/N510129/1] Funding Source: UKRI
  12. ESRC [ES/T007370/1] Funding Source: UKRI
  13. MRC [MC_PC_19009] Funding Source: UKRI
  14. Wellcome Trust [105612/Z/14/Z] Funding Source: Wellcome Trust

向作者/读者索取更多资源

Research shows that peer victimisation and genetic factors can independently predict depressive symptoms and wellbeing in early adulthood. However, the decrease in mental health and wellbeing following victimisation cannot be solely attributed to the moderating effect of genetic factors at present.
Previous studies suggest an individual's risk of depression following adversity may be moderated by their genetic liability. No study, however, has examined peer victimisation, an experience repeatedly associated with mental illness. We explore whether the negative mental health outcomes following victimisation can be partly attributed to genetic factors using polygenic scores for depression and wellbeing. Among participants from the Avon Longitudinal Study of Parents and Children (ALSPAC), we show that polygenic scores and peer victimisation are significant independent predictors of depressive symptoms (n=2268) and wellbeing (n=2299) in early adulthood. When testing for interaction effects, our results lead us to conclude that low mental health and wellbeing following peer victimisation is unlikely to be explained by a moderating effect of genetic factors, as indexed by current polygenic scores. Genetic profiling is therefore unlikely to be effective in identifying those more vulnerable to the effects of victimisation at present. The reasons why some go on to experience mental health problems following victimisation, while others remain resilient, requires further exploration, but our results rule out a major influence of current polygenic scores.

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