期刊
BASIC & CLINICAL PHARMACOLOGY & TOXICOLOGY
卷 130, 期 1, 页码 122-131出版社
WILEY
DOI: 10.1111/bcpt.13680
关键词
adults; asthma; drug utilisation; glucocorticoids; pharmacoepidemiology
资金
- University of Southern Denmark
- Region of Southern Denmark
- AstraZeneca
From 1999 to 2018, the prevalence of OCS users among young adults with active asthma in Denmark has remained relatively stable, with a decrease in high-users and annual consumption.
Oral corticosteroids (OCS) are used in asthma management but can cause serious adverse effects. We aimed to investigate the usage trends in a nationwide asthma cohort in Denmark from 1999 to 2018. Using national registers, we identified young adults (18-45 years) with two or more asthma drug collections within 12 months since the age of 15 years as indicative of active asthma. OCS exposure level was stratified as high use (>= 5 mg prednisolone/day/year) and low use (<5 mg/day/year). Lorenz curves were computed to illustrate potential skewness of consumption among the OCS users. We identified 318 950 individuals with a median age of 29 years (IQR 20-38 years) whereof 57% were women. The 1-year prevalence of OCS users was stable at 4.8% (median, IQR 4.7%-4.8%), but with nearly 40% decrease in high-users from 0.54% in 1999 to 0.33% in 2018. The median annual exposure decreased from 500 mg/year (1999) to 250 mg/year (2018). We found a substantial skewness in the distribution of OCS usage with 10% of users accounting for almost 50% of all OCS use. The prevalence of OCS users among young adults with active asthma has been relatively stable from 1999 to 2018, but with a decreasing prevalence of high-users and annual consumption.
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