4.5 Article

Changes in oral corticosteroid use in asthma treatment-A 20-year Danish nationwide drug utilisation study

期刊

BASIC & CLINICAL PHARMACOLOGY & TOXICOLOGY
卷 130, 期 1, 页码 122-131

出版社

WILEY
DOI: 10.1111/bcpt.13680

关键词

adults; asthma; drug utilisation; glucocorticoids; pharmacoepidemiology

资金

  1. University of Southern Denmark
  2. Region of Southern Denmark
  3. AstraZeneca

向作者/读者索取更多资源

From 1999 to 2018, the prevalence of OCS users among young adults with active asthma in Denmark has remained relatively stable, with a decrease in high-users and annual consumption.
Oral corticosteroids (OCS) are used in asthma management but can cause serious adverse effects. We aimed to investigate the usage trends in a nationwide asthma cohort in Denmark from 1999 to 2018. Using national registers, we identified young adults (18-45 years) with two or more asthma drug collections within 12 months since the age of 15 years as indicative of active asthma. OCS exposure level was stratified as high use (>= 5 mg prednisolone/day/year) and low use (<5 mg/day/year). Lorenz curves were computed to illustrate potential skewness of consumption among the OCS users. We identified 318 950 individuals with a median age of 29 years (IQR 20-38 years) whereof 57% were women. The 1-year prevalence of OCS users was stable at 4.8% (median, IQR 4.7%-4.8%), but with nearly 40% decrease in high-users from 0.54% in 1999 to 0.33% in 2018. The median annual exposure decreased from 500 mg/year (1999) to 250 mg/year (2018). We found a substantial skewness in the distribution of OCS usage with 10% of users accounting for almost 50% of all OCS use. The prevalence of OCS users among young adults with active asthma has been relatively stable from 1999 to 2018, but with a decreasing prevalence of high-users and annual consumption.

作者

我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。

评论

主要评分

4.5
评分不足

次要评分

新颖性
-
重要性
-
科学严谨性
-
评价这篇论文

推荐

暂无数据
暂无数据