Plant virus infection disrupts vacuolar acidification and autophagic degradation for the effective infection

Summary: The study reveals that the replicase gamma a of Barley stripe mosaic virus can inhibit vacuolar acidification and suppress autophagic degradation to promote viral infection in plants. The disruption of vacuolar acidification seems to be a common viral counter-defense strategy employed by multiple viruses, highlighting the importance of functional vacuolar acidification in plant antiviral defense.