4.8 Article

m6A reader YTHDC1 modulates autophagy by targeting SQSTM1 in diabetic skin

相关参考文献

注意:仅列出部分参考文献,下载原文获取全部文献信息。
Article Cell Biology

m6A mRNA methylation regulates testosterone synthesis through modulating autophagy in Leydig cells

Yabing Chen et al.

Summary: The study reveals a negative association between m(6)A modification and autophagy in Leydig cells during testosterone synthesis. The regulation of METTL14, ALKBH5, and m(6)A influences AMP-activated protein kinase activity and subsequent autophagy in Leydig cells. Human chorionic gonadotropin treatment modulates m(6)A modification by upregulating ALKBH5 and decreasing METTL14, affecting the synthesis of testosterone.

AUTOPHAGY (2021)

Article Gastroenterology & Hepatology

N6-Methyladenosine Reader Protein YT521-B Homology Domain-Containing 2 Suppresses Liver Steatosis by Regulation of mRNA Stability of Lipogenic Genes

Bing Zhou et al.

Summary: In this study, it was found that m(6)A enrichment and mRNA expression of lipogenic genes were increased in leptin-receptor-deficient mice. The m(6)A reader, Ythdc2, was down-regulated in obese mice and NAFLD patients, and its suppression in lean mice led to TG accumulation while overexpression in obese mice improved liver steatosis and insulin resistance. This suggests that Ythdc2 plays a crucial role in regulating hepatic lipogenesis and TG homeostasis, presenting a potential target for treating obesity-related NAFLD.

HEPATOLOGY (2021)

Review Genetics & Heredity

Molecular Mechanisms Driving mRNA Degradation by m(6)A Modification

Yujin Lee et al.

TRENDS IN GENETICS (2020)

Article Dermatology

Autophagy activators stimulate the removal of advanced glycation end products in human keratinocytes

T. Laughlin et al.

JOURNAL OF THE EUROPEAN ACADEMY OF DERMATOLOGY AND VENEREOLOGY (2020)

Article Endocrinology & Metabolism

Glucose Is Involved in the Dynamic Regulation of m6A in Patients With Type 2 Diabetes

Ying Yang et al.

JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM (2019)

Review Biochemistry & Molecular Biology

Targeting Autophagy to Overcome Human Diseases

Maria Condello et al.

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES (2019)

Review Medical Laboratory Technology

Targeting epigenetic mechanisms in diabetic wound healing

Aaron Den Dekker et al.

TRANSLATIONAL RESEARCH (2019)

Review Biochemistry & Molecular Biology

Where, When, and How: Context-Dependent Functions of RNA Methylation Writers, Readers, and Erasers

Hailing Shi et al.

MOLECULAR CELL (2019)

Article Biochemistry & Molecular Biology

Hyperosmotic Stress Induces Unconventional Autophagy Independent of the Ulk1 Complex

Naoki Tamura et al.

MOLECULAR AND CELLULAR BIOLOGY (2019)

Article Multidisciplinary Sciences

Metascape provides a biologist-oriented resource for the analysis of systems-level datasets

Yingyao Zhou et al.

NATURE COMMUNICATIONS (2019)

Article Multidisciplinary Sciences

Autophagy controls reactive oxygen species homeostasis in guard cells that is essential for stomatal opening

Shota Yamauchi et al.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2019)

Editorial Material Cell Biology

Mechanistic insight into the regulation of SQSTM1/p62

Yi Zhang et al.

AUTOPHAGY (2019)

Article Biochemistry & Molecular Biology

Autophagy is required for the directed motility of keratinocytes driven by electric fields

Tiantian Yan et al.

FASEB JOURNAL (2019)

Review Physiology

WOUND HEALING: A CELLULAR PERSPECTIVE

Melanie Rodrigues et al.

PHYSIOLOGICAL REVIEWS (2019)

Article Biochemistry & Molecular Biology

Negative Regulation of the Keap1-Nrf2 Pathway by a p62/Sqstm1 Splicing Variant

Shun Kageyama et al.

MOLECULAR AND CELLULAR BIOLOGY (2018)

Review Cell Biology

Skin Cell Heterogeneity in Development, Wound Healing, and Cancer

Emanuel Rognoni et al.

TRENDS IN CELL BIOLOGY (2018)

Review Immunology

More Than Skin Deep: Autophagy Is Vital for Skin Barrier Function

Payel Sil et al.

FRONTIERS IN IMMUNOLOGY (2018)

Review Genetics & Heredity

Structural Insights into N6-methyladenosine (m6A) Modification in the Transcriptome

Jinbo Huang et al.

GENOMICS PROTEOMICS & BIOINFORMATICS (2018)

Article Multidisciplinary Sciences

ZZ-dependent regulation of p62/SQSTM1 in autophagy

Yi Zhang et al.

NATURE COMMUNICATIONS (2018)

Article Cell & Tissue Engineering

Inhibition of autophagy promoted high glucose/ROS-mediated apoptosis in ADSCs

Qiang Li et al.

STEM CELL RESEARCH & THERAPY (2018)

Review Medicine, General & Internal

Global epidemiology of diabetic foot ulceration: a systematic review and meta-analysis

Pengzi Zhang et al.

ANNALS OF MEDICINE (2017)

Review Cell Biology

Posttranslational control of HuR function

Ioannis Grammatikakis et al.

WILEY INTERDISCIPLINARY REVIEWS-RNA (2017)

Review Biochemistry & Molecular Biology

Regulation of selective autophagy: the p62/SQSTM1 paradigm

Trond Lamark et al.

SIGNALLING MECHANISMS IN AUTOPHAGY (2017)

Review Biochemistry & Molecular Biology

Diabetes and Wound Angiogenesis

Uzoagu A. Okonkwo et al.

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES (2017)

Review Immunology

Macrophage-Mediated Inflammation in Normal and Diabetic Wound Healing

Anna E. Boniakowski et al.

JOURNAL OF IMMUNOLOGY (2017)

Review Biotechnology & Applied Microbiology

Pharmacological modulation of autophagy: therapeutic potential and persisting obstacles

Lorenzo Galluzzi et al.

NATURE REVIEWS DRUG DISCOVERY (2017)

Review Endocrinology & Metabolism

Multifunctional p62 Effects Underlie Diverse Metabolic Diseases

Min Long et al.

TRENDS IN ENDOCRINOLOGY AND METABOLISM (2017)

Article Oncology

Hyperosmotic stress stimulates autophagy via polycystin-2

Daniel Pena-Oyarzun et al.

ONCOTARGET (2017)

Review Biochemistry & Molecular Biology

Dynamic RNA Modifications in Gene Expression Regulation

Ian A. Roundtree et al.

Article Endocrinology & Metabolism

An Essential Role of NRF2 in Diabetic Wound Healing

Min Long et al.

DIABETES (2016)

Article Biochemistry & Molecular Biology

AGEs trigger autophagy in diabetic skin tissues and fibroblasts

Kan Sun et al.

BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS (2016)

Review Dermatology

High-glucose environment disturbs the physiologic functions of keratinocytes: Focusing on diabetic wound healing

Stephen Chu-Sung Hu et al.

JOURNAL OF DERMATOLOGICAL SCIENCE (2016)

Article Biochemistry & Molecular Biology

Nuclear m6A Reader YTHDC1 Regulates mRNA Splicing

Wen Xiao et al.

MOLECULAR CELL (2016)

Article Cell Biology

AGE-induced keratinocyte MMP-9 expression is linked to TET2-mediated CpG demethylation

Jinglu Zhang et al.

WOUND REPAIR AND REGENERATION (2016)

Review Biochemistry & Molecular Biology

p62/SQSTM1 functions as a signaling hub and an autophagy adaptor

Yoshinori Katsuragi et al.

FEBS JOURNAL (2015)

Article Endocrinology & Metabolism

Decreased N-6-Methyladenosine in Peripheral Blood RNA From Diabetic Patients Is Associated With FTO Expression Rather Than ALKBH5

Fan Shen et al.

JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM (2015)

Review Medicine, Research & Experimental

mTOR: a pharmacologic target for autophagy regulation

Young Chul Kim et al.

JOURNAL OF CLINICAL INVESTIGATION (2015)

Review Genetics & Heredity

Targeting autophagy in skin diseases

Teng Yu et al.

JOURNAL OF MOLECULAR MEDICINE-JMM (2015)

Review Cell Biology

Autophagy regulation by nutrient signaling

Ryan C. Russell et al.

CELL RESEARCH (2014)

Article Multidisciplinary Sciences

N6-methyladenosine-dependent regulation of messenger RNA stability

Xiao Wang et al.

NATURE (2014)

Article Cell Biology

Rapamycin reduces burn wound progression by enhancing autophagy in deep second-degree burn in rats

Mengjing Xiao et al.

WOUND REPAIR AND REGENERATION (2013)

Review Biochemistry & Molecular Biology

p62 at the Interface of Autophagy, Oxidative Stress Signaling, and Cancer

Ioannis P. Nezis et al.

ANTIOXIDANTS & REDOX SIGNALING (2012)

Article Multidisciplinary Sciences

Topology of the human and mouse m6A RNA methylomes revealed by m6A-seq

Dan Dominissini et al.

NATURE (2012)

Article Dermatology

Reduced Dermis Thickness and AGE Accumulation in Diabetic Abdominal Skin

Yiwen Niu et al.

INTERNATIONAL JOURNAL OF LOWER EXTREMITY WOUNDS (2012)

Review Biochemistry & Molecular Biology

Feedback on Fat: p62-mTORC1-Autophagy Connections

Jorge Moscat et al.

Review Biochemistry & Molecular Biology

Regulation of autophagy by ROS: physiology and pathology

Ruth Scherz-Shouval et al.

TRENDS IN BIOCHEMICAL SCIENCES (2011)

Review Cardiac & Cardiovascular Systems

Oxidative Stress and Diabetic Complications

Ferdinando Giacco et al.

CIRCULATION RESEARCH (2010)

Article Biochemistry & Molecular Biology

Physical and Functional Interaction of Sequestosome 1 with Keap1 Regulates the Keap1-Nrf2 Cell Defense Pathway

Ian M. Copple et al.

JOURNAL OF BIOLOGICAL CHEMISTRY (2010)

Review Dentistry, Oral Surgery & Medicine

Factors Affecting Wound Healing

S. Guo et al.

JOURNAL OF DENTAL RESEARCH (2010)

Review Biochemistry & Molecular Biology

Regulation of Autophagy by Reactive Oxygen Species (ROS): Implications for Cancer Progression and Treatment

Meghan B. Azad et al.

ANTIOXIDANTS & REDOX SIGNALING (2009)

Review Biochemistry & Molecular Biology

p62 at the Crossroads of Autophagy, Apoptosis, and Cancer

Jorge Moscat et al.

Review Multidisciplinary Sciences

Wound repair and regeneration

Geoffrey C. Gurtner et al.

NATURE (2008)

Review Medicine, General & Internal

Wound healing and its impairment in the diabetic foot

V Falanga

LANCET (2005)

Review Biochemistry & Molecular Biology

HuR and mRNA stability

CM Brennan et al.

CELLULAR AND MOLECULAR LIFE SCIENCES (2001)