期刊
AUTOPHAGY
卷 18, 期 2, 页码 443-448出版社
TAYLOR & FRANCIS INC
DOI: 10.1080/15548627.2021.1971380
关键词
Cargo; degradation; homeostasis; macronucleophagy; membrane; micronucleophagy; mode; nucleus; nucleophagy; vacuole
类别
资金
- National Institute of General Medical Sciences [GM131919]
Nucleophagy is a selective subtype of autophagy that targets specific portions of the nucleus for degradation, and further research on its signaling, regulation, molecular mechanisms, and cargo composition is crucial in advancing our understanding of this critical cellular process.
Nucleophagy, the selective subtype of autophagy that predominantly targets only a selected and (nonessential) portion of the nucleus, and rarely the nucleus in its entirety, for degradation, reinforces the paradigm that nucleophagy recycling is a meticulous and highly delicate process guarded by fail-safe mechanisms. Our goal in this commentary is to encourage autophagy researchers and other scientists to explore nucleophagy blind spots and gain advanced insights into the diverse roles of this process and its selective modality as they pertain to intranuclear quality control and cellular homeostasis. Identifying and deciphering nucleophagic signaling, regulation, molecular mechanism(s) and its mediators, cargo composition and nuclear membrane dynamics under numerous physiological and/or pathological settings will provide important advances in our understanding of this critical type of organelle-selective autophagy.
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