期刊
AUTOIMMUNITY REVIEWS
卷 21, 期 2, 页码 -出版社
ELSEVIER
DOI: 10.1016/j.autrev.2021.102976
关键词
Membranous nephropathy; Autoantigens; Autoimmune response; Podocyte injury; Biomarkers; Course monitoring
类别
资金
- National Key Research and Develop-ment Project [2019YFC1710104]
- National Natural Science Foun-dation of China [91942301]
Membranous nephropathy (MN) is a common pattern of glomerular injury in multiple autoimmune responses. Detecting autoantibodies can lead to personalized precision medicine. Further identification of autoantibodies and biomarkers is needed to accurately predict disease prognosis and therapeutic response.
A variety of podocyte antigens have been identified in human membranous nephropathy (MN), which is divided into various antigen-dominated subtypes, confirming the concept that MN is the common pattern of glomerular injury in multiple autoimmune responses. The detection of autoantibodies, which has been widely used in the clinical practice of MN, may lead to personalized precision medicine. However, given the potential risks of immunosuppressive therapy, more autoantibodies and biomarkers need to be identified to predict the prognosis and therapeutic response of MN more accurately. In this review, we attempted to summarize the autoantigens/ autoantibodies and autoimmune mechanisms that can predict disease states based on the current understanding of MN pathogenesis, especially the podocyte injury manifestations. In conclusion, both the autoimmune response and podocyte injury require multidimensional attention in the disease course of MN.
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