期刊
ATMOSPHERIC ENVIRONMENT
卷 275, 期 -, 页码 -出版社
PERGAMON-ELSEVIER SCIENCE LTD
DOI: 10.1016/j.atmosenv.2022.119005
关键词
Lipid profiles; PM2.5 components; Polycyclic aromatic hydrocarbons (PAH); Repeated measurements
资金
- China Medical Board [15-230]
- China Prospective cohort study of Air pollution and health effects in Typical areas (C-PAT) [MEE-EH-20190802]
- Fundamental Research Funds for the Central Universities [3332020087]
- Chinese Academy of Medical Science Innovation Fund for Medical Sciences [2017-I2M-1-009]
This study investigated the relationship between multiple categories of PAHs and lipid profiles. The results showed that exposure to multiple categories of PAHs may lead to adverse lipid profiles, including decreased HDL-C levels and increased total cholesterol.
Lipid disorder has been demonstrated to be a key biomarker for many chronic diseases, and PM2.5 is emerging as a risk factor for altered lipid profiles. However, few studies have focused on changes in comprehensive lipid indices caused by PM2.5-bound polycyclic aromatic hydrocarbon (PAH) exposure in the older adult population. The aim of this study was to investigate the relationship between multiple categories of PAHs and lipid profiles. This longitudinal study including 98 adults was conducted in Beijing, China, from November 2016 to January 2018. PAHs were analyzed using gas chromatography-mass spectrometry in the ion monitoring mode. Multiple categories of PAHs were classified as low-molecular-weight PAHs (LMW-PAHs), high-molecular-weight PAHs (HMW-PAHs), carcinogenic PAHs (c-PAHs) and noncarcinogenic PAHs (nc-PAHs) based on their molecular weights and carcinogenicity potentials. Linear mixed-effects models were used to explore the association between multiple categories of PAHs and lipid profiles, including single-pollutant, two-pollutant, and constituent residual models. High-density lipoprotein cholesterol (HDL-C) levels were significantly decreased by 1.00% (95% CI,-1.98% to-0.30%) to 9.52% (95% CI,-13.93% to-4.88%) in association with a 10-ng/m(3) increase in moving averages of the multiple categories of PAHs. In addition, significant increases in the total cholesterol (TG), castelli risk indices I and II (CRI-I and II), atherogenic coefficient (AC) and atherogenic index of plasma (AIP) of 2.02% (95% CI, 0.10%-5.13%) to 40.49% (95% CI, 13.88%-73.33%) were found, associated with a 10ng/m(3) increase in multiple categories of PAHs. Our findings suggest that exposure to multiple categories of PAHs may disturb proatherogenic lipid profiles. Further studies are needed to investigate the potential mechanism by which PAHs disturb lipid metabolism.
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