期刊
ATHEROSCLEROSIS
卷 338, 期 -, 页码 46-54出版社
ELSEVIER IRELAND LTD
DOI: 10.1016/j.atherosclerosis.2021.11.005
关键词
Maternal PlGF; Maternal sFlt-1; Pregnancy; Childhood vascular development
资金
- Erasmus Medical Center, Rotterdam
- Erasmus University Rotterdam
- Netherlands Organization for Health Research and Development
- Dutch Heart Foundation [2017T013]
- Dutch Diabetes Foundation [2017.81.002]
- Netherlands Organization for Health Research and Development (NWO, ZonMW) [543003109]
- European Union's Horizon 2020 research and innovation programme under the ERA-NET Cofund action [727565]
- ZonMW the Netherlands [529051026]
- Netherlands Organization for Health Research and Development (NWO) [ZonMw-VIDI 016.136.361]
- European Research Council Consolidator Grant [ERC-2014-CoG-648916]
- EndObesity
This study found that maternal angiogenic factors in the first half of pregnancy are not associated with childhood blood pressure and vascular development in the total population. Only in children born preterm, higher maternal second trimester PlGF concentrations are associated with lower childhood diastolic blood pressure.
Background and aims: Reduced maternal placental growth factor (PlGF) and higher soluble fms-like tyrosine kinase (sFlt-1) concentrations in pregnancy may have persistent effects on offspring vasculature. We hypothesized that suboptimal maternal angiogenic factors in pregnancy may adversely affect fetal vascular development, leading to an increased risk of adverse atheriosclerotic adaptations and higher blood pressure in offspring. Methods: In a population-based prospective cohort among 4565 women and their offspring, we examined the associations of maternal serum PlGF and sFlt-1 concentrations in the first half of pregnancy with offspring vascular development. We measured childhood blood pressure and obtained childhood carotid intima media thickness and carotid distensibility through ultrasonography at 9 years. Results: After adjustment for maternal sociodemographic and lifestyle characteristics, no associations were present of maternal first and second trimester angiogenic factors with childhood blood pressure, carotid intima media thickness (IMT) or distensibility in the total population. In preterm born children only, higher maternal second trimester PlGF concentrations, but not sFlt-1 concentrations, were associated with a lower childhood diastolic blood pressure (difference: -0.16 SDS (95% CI -0.30, -0.03) per SDS increase in maternal second trimester PlGF concentration). No associations among children born small-for-gestational age were present. Conclusions: In a low-risk population, maternal angiogenic factors in the first half of pregnancy are not associated with childhood blood pressure, carotid IMT or carotid distensibility after considering maternal sociodemographic and lifestyle factors. Only in children born preterm, lower maternal second trimester PlGF concentrations are associated with higher childhood diastolic blood pressure, but not with other vascular outcomes.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据