4.2 Editorial Material

Treating Neutrophilic Inflammation in Airways Diseases

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Article Critical Care Medicine

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Summary: Bronchiectasis is a neutrophilic inflammatory disease, and research has shown that neutrophilic inflammation is associated with disease severity and treatment response. Studying the role of NETs in bronchiectasis can help develop new treatment strategies.

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An Inhaled PI3Kδ Inhibitor Improves Recovery in Acutely Exacerbating COPD Patients: A Randomized Trial

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Summary: This study evaluated the safety and efficacy of inhaled nemiralisib in patients with an acute exacerbation of COPD. Results showed that adding nemiralisib to standard care improved recovery and lung function parameters. Despite post-inhalation cough being identified as a common adverse event, nemiralisib was well tolerated, offering a promising novel therapy for acutely ill COPD patients.

INTERNATIONAL JOURNAL OF CHRONIC OBSTRUCTIVE PULMONARY DISEASE (2021)

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New Pharmacological Tools to Target Leukocyte Trafficking in Lung Disease

Kylie B. R. Belchamber et al.

Summary: In response to lung infection and inflammation, immune cells are recruited to the site of infection. However, in advanced age and lung disease, this balance can be disrupted leading to an excessive influx of immune cells and inflammation in the airways, which can increase host damage and impair the host's ability to respond effectively to microbial invasion. Targeting leukocyte migration as an immunotherapeutic approach could hold promise in treating lung diseases.

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THE NEUTROPHIL'S ROLE DURING HEALTH AND DISEASE

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Letter Respiratory System

Neutrophil extracellular trap formation is regulated by CXCR2 in COPD neutrophils

Frauke Pedersen et al.

EUROPEAN RESPIRATORY JOURNAL (2018)

Article Infectious Diseases

The Dual Role of Neutrophils in HIV Infection

Tiffany Hensley-McBain et al.

CURRENT HIV/AIDS REPORTS (2018)

Article Respiratory System

Clinical and inflammatory characteristics of the European U-BIOPRED adult severe asthma cohort

Dominick E. Shaw et al.

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Phase II study of a neutrophil elastase inhibitor (AZD9668) in patients with bronchiectasis

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AZD9668, a neutrophil elastase inhibitor, plus ongoing budesonide/formoterol in patients with COPD

Piotr Kuna et al.

RESPIRATORY MEDICINE (2012)