4.7 Article

Post-VX exposure treatment of rats with engineered phosphotriesterases

相关参考文献

注意:仅列出部分参考文献,下载原文获取全部文献信息。
Editorial Material Medicine, General & Internal

Novichok nerve agent poisoning

David Steindl et al.

LANCET (2021)

Article Toxicology

Catalytic activity and stereoselectivity of engineered phosphotriesterases towards structurally different nerve agents in vitro

Anja Kohler et al.

Summary: The study investigated the catalytic efficacies of five BdPTE mutants and modified versions with delayed plasma clearance, as well as a bispecific BdPTE with broadened substrate spectrum. The newly developed enzymes BdPTE-4 and BdPTE-7 exhibited high catalytic efficacy towards structurally different nerve agents and stereoselectivity towards the toxic P(-) VX enantiomer in vitro.

ARCHIVES OF TOXICOLOGY (2021)

Article Biochemistry & Molecular Biology

Prospects of PASylation® for the design of protein and peptide therapeutics with extended half-life and enhanced action

Michaela Gebauer et al.

BIOORGANIC & MEDICINAL CHEMISTRY (2018)

Article Toxicology

Novichok: a murderous nerve agent attack in the UK

J. Allister Vale et al.

CLINICAL TOXICOLOGY (2018)

Review Biochemistry & Molecular Biology

Cholinesterase reactivators and bioscavengers for pre- and post-exposure treatments of organophosphorus poisoning

Patrick Masson et al.

JOURNAL OF NEUROCHEMISTRY (2017)

Article Biochemistry & Molecular Biology

Overcoming an optimization plateau in the directed evolution of highly efficient nerve agent bioscavengers

Moshe Goldsmith et al.

PROTEIN ENGINEERING DESIGN & SELECTION (2017)

Article Biochemistry & Molecular Biology

Oximes in organophosphate poisoning: 60 years of hope and despair

Franz Worek et al.

CHEMICO-BIOLOGICAL INTERACTIONS (2016)

Article Toxicology

Catalytic bioscavengers in nerve agent poisoning: A promising approach?

Franz Worek et al.

TOXICOLOGY LETTERS (2016)

Article Biochemistry & Molecular Biology

Variants of Phosphotriesterase for the Enhanced Detoxification of the Chemical Warfare Agent VR

Andrew N. Bigley et al.

BIOCHEMISTRY (2015)

Article Chemistry, Multidisciplinary

Acute toxicity of some nerve agents and pesticides in rats

Jan Misik et al.

DRUG AND CHEMICAL TOXICOLOGY (2015)

Article Biochemistry & Molecular Biology

Engineering V-Type Nerve Agents Detoxifying Enzymes Using Computationally Focused Libraries

Izhack Cherny et al.

ACS CHEMICAL BIOLOGY (2013)

Article Biochemistry & Molecular Biology

Limitations and challenges in treatment of acute chemical warfare agent poisoning

Horst Thiermann et al.

CHEMICO-BIOLOGICAL INTERACTIONS (2013)

Article Chemistry, Multidisciplinary

Enzymatic Neutralization of the Chemical Warfare Agent VX: Evolution of Phosphotriesterase for Phosphorothiolate Hydrolysis

Andrew N. Bigley et al.

JOURNAL OF THE AMERICAN CHEMICAL SOCIETY (2013)

Review Pharmacology & Pharmacy

The value of novel oximes for treatment of poisoning by organophosphorus compounds

Franz Worek et al.

PHARMACOLOGY & THERAPEUTICS (2013)

Article Biochemistry & Molecular Biology

PASylation: a biological alternative to PEGylation for extending the plasma half-life of pharmaceutically active proteins

Martin Schlapschy et al.

PROTEIN ENGINEERING DESIGN & SELECTION (2013)

Article Biochemical Research Methods

Simultaneous quantification of VX and its toxic metabolite in blood and plasma samples and its application for in vivo and in vitro toxicological studies

Georg Reiter et al.

JOURNAL OF CHROMATOGRAPHY B-ANALYTICAL TECHNOLOGIES IN THE BIOMEDICAL AND LIFE SCIENCES (2011)

Article Biochemistry & Molecular Biology

Percutaneous exposure to the nerve agent VX: Efficacy of combined atropine, obidoxime and diazepam treatment

Marloes J. A. Joosen et al.

CHEMICO-BIOLOGICAL INTERACTIONS (2010)

Article Biochemical Research Methods

Chromatographic resolution, characterisation and quantification of VX enantiomers in hemolysed swine blood samples

Georg Reiter et al.

JOURNAL OF CHROMATOGRAPHY B-ANALYTICAL TECHNOLOGIES IN THE BIOMEDICAL AND LIFE SCIENCES (2008)

Article Biochemical Research Methods

The Strep-tag system for one-step purification and high-affinity detection or capturing of proteins

Thomas G. M. Schmidt et al.

NATURE PROTOCOLS (2007)

Article Clinical Neurology

Sarin experiences in Japan: Acute toxicity and long-term effects

N. Yanagisawa et al.

JOURNAL OF THE NEUROLOGICAL SCIENCES (2006)

Article Clinical Neurology

The acute treatment of nerve agent exposure

Kevin Cannard

JOURNAL OF THE NEUROLOGICAL SCIENCES (2006)