4.7 Article

Acute effects of the imidacloprid metabolite desnitro-imidacloprid on human nACh receptors relevant for neuronal signaling

相关参考文献

注意:仅列出部分参考文献,下载原文获取全部文献信息。
Article Toxicology

Human neuronal signaling and communication assays to assess functional neurotoxicity

Dominik Loser et al.

Summary: This study introduces an alternative system for evaluating signaling in human neurons and networks, using high-throughput quantification of free intracellular Ca2+ concentrations in LUHMES cultures. The results demonstrate the broad applicability of this system for assessing and characterizing various types of neuronal signaling and potential disturbances, such as modulation of ion channels and neurotransmitter activity.

ARCHIVES OF TOXICOLOGY (2021)

Article Toxicology

Neurotoxicity and underlying cellular changes of 21 mitochondrial respiratory chain inhibitors

Johannes Delp et al.

Summary: The study utilized 21 pesticides described as mitochondrial inhibitors to investigate the adverse outcome pathway (AOP:3) of Parkinson's disease, finding that some inhibitors triggered neurodegeneration while others did not. There was a clear hierarchy of assay sensitivity, with mitochondrial failure being much more sensitive than neurite damage in predicting toxic reactions.

ARCHIVES OF TOXICOLOGY (2021)

Article Toxicology

Functional alterations by a subgroup of neonicotinoid pesticides in human dopaminergic neurons

Dominik Loser et al.

Summary: The study demonstrates that several neonicotinoid pesticides can trigger human neuronal signaling at low micromolar concentrations, raising concerns about their potential impact on nervous system development.

ARCHIVES OF TOXICOLOGY (2021)

Article Biochemistry & Molecular Biology

Insecticides, biologics and nematicides: Updates to IRAC's mode of action classification - a tool for resistance management

Thomas C. Sparks et al.

PESTICIDE BIOCHEMISTRY AND PHYSIOLOGY (2020)

Article Medicine, Research & Experimental

Incorporation of Stem Cell-Derived Astrocytes into Neuronal Organoids to Allow Neuro-Glial Interactions in Toxicological Studies

Markus Bruell et al.

ALTEX-ALTERNATIVES TO ANIMAL EXPERIMENTATION (2020)

Article Environmental Sciences

Five degradates of imidacloprid in source water, treated water, and tap water in Wuhan, central China

Yanjian Wan et al.

SCIENCE OF THE TOTAL ENVIRONMENT (2020)

Article Medicine, Research & Experimental

Internationalization of Read-Across as a Validated New Approach Method (NAM) for Regulatory Toxicology

Costanza Rovida et al.

ALTEX-ALTERNATIVES TO ANIMAL EXPERIMENTATION (2020)

Article Toxicology

Development of a neurotoxicity assay that is tuned to detect mitochondrial toxicants

Johannes Delp et al.

ARCHIVES OF TOXICOLOGY (2019)

Article Environmental Sciences

Trends in neonicotinoid pesticide residues in food and water in the United States, 1999-2015

Hillary A. Craddock et al.

ENVIRONMENTAL HEALTH (2019)

Article Engineering, Environmental

Chlorinated Byproducts of Neonicotinoids and Their Metabolites: An Unrecognized Human Exposure Potential?

Kathryn L. Klarich Wong et al.

ENVIRONMENTAL SCIENCE & TECHNOLOGY LETTERS (2019)

Article Multidisciplinary Sciences

Mitochondrial Stress Response in Neural Stem Cells Exposed to Electronic Cigarettes

Atena Zahedi et al.

ISCIENCE (2019)

Article Pharmacology & Pharmacy

Stage-specific metabolic features of differentiating neurons: Implications for toxicant sensitivity

Johannes Delp et al.

TOXICOLOGY AND APPLIED PHARMACOLOGY (2018)

Article Biotechnology & Applied Microbiology

The metabolism of imidacloprid by aldehyde oxidase contributes to its clastogenic effect in New Zealand rabbits

Alexander I. Vardavas et al.

MUTATION RESEARCH-GENETIC TOXICOLOGY AND ENVIRONMENTAL MUTAGENESIS (2018)

Article Medicine, Research & Experimental

A High-Throughput Approach to Identify Specific Neurotoxicants / Developmental Toxicants in Human Neuronal Cell Function Assays

Johannes Delp et al.

ALTEX-ALTERNATIVES TO ANIMAL EXPERIMENTATION (2018)

Article Multidisciplinary Sciences

Mammalian Susceptibility to a Neonicotinoid Insecticide after Fetal and Early Postnatal Exposure

Andrew P. Burke et al.

SCIENTIFIC REPORTS (2018)

Review Environmental Sciences

Effects of Neonicotinoid Pesticide Exposure on Human Health: A Systematic Review

Andria M. Cimino et al.

ENVIRONMENTAL HEALTH PERSPECTIVES (2017)

Article Engineering, Environmental

Occurrence of Neonicotinoid Insecticides in Finished Drinking Water and Fate during Drinking Water Treatment

Kathryn L. Klarich et al.

ENVIRONMENTAL SCIENCE & TECHNOLOGY LETTERS (2017)

Article Toxicology

Adverse outcome pathways: opportunities, limitations and open questions

Marcel Leist et al.

ARCHIVES OF TOXICOLOGY (2017)

Article Multidisciplinary Sciences

X-ray structure of the human α4β2 nicotinic receptor

Claudio L. Morales-Perez et al.

NATURE (2016)

Article Biochemistry & Molecular Biology

Preferential Extracellular Generation of the Active Parkinsonian Toxin MPP+ by Transporter-Independent Export of the Intermediate MPDP+

Stefan Schildknecht et al.

ANTIOXIDANTS & REDOX SIGNALING (2015)

Review Pharmacology & Pharmacy

Cholinergic modulation of dopamine pathways through nicotinic acetylcholine receptors

Sybren F. de Kloet et al.

BIOCHEMICAL PHARMACOLOGY (2015)

Article Biochemistry & Molecular Biology

Toxicity of organic and inorganic mercury species in human neurons and human astrocytes

Hanna Lohren et al.

JOURNAL OF TRACE ELEMENTS IN MEDICINE AND BIOLOGY (2015)

Review Neurosciences

Diversity of native nicotinic receptor subtypes in mammalian brain

Michele Zoli et al.

NEUROPHARMACOLOGY (2015)

Review Biochemistry & Molecular Biology

The global status of insect resistance to neonicotinoid insecticides

Chris Bass et al.

PESTICIDE BIOCHEMISTRY AND PHYSIOLOGY (2015)

Article Biochemistry & Molecular Biology

IRAC: Mode of action classification and insecticide resistance management

Thomas C. Sparks et al.

PESTICIDE BIOCHEMISTRY AND PHYSIOLOGY (2015)

Article Environmental Sciences

Systemic insecticides (neonicotinoids and fipronil): trends, uses, mode of action and metabolites

N. Simon-Delso et al.

ENVIRONMENTAL SCIENCE AND POLLUTION RESEARCH (2015)

Article Multidisciplinary Sciences

Dose-Response Analysis Using R

Christian Ritz et al.

PLOS ONE (2015)

Article Chemistry, Multidisciplinary

Cell-based assays for Parkinson's disease using differentiated human LUHMES cells

Xiao-min Zhang et al.

ACTA PHARMACOLOGICA SINICA (2014)

Article Agriculture, Multidisciplinary

Quantitative Analysis of Neonicotinoid Insecticide Residues in Foods: Implication for Dietary Exposures

Mei Chen et al.

JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY (2014)

Review Clinical Neurology

Neurobehavioural effects of developmental toxicity

Philippe Grandjean et al.

LANCET NEUROLOGY (2014)

Article Multidisciplinary Sciences

Acute Activation, Desensitization and Smoldering Activation of Human Acetylcholine Receptors

Barbara G. Campling et al.

PLOS ONE (2013)

Article Medicine, Research & Experimental

Generation of Genetically-Modified Human Differentiated Cells for Toxicological Tests and the Study of Neurodegenerative Diseases

Stefan Schildknecht et al.

ALTEX-ALTERNATIVES TO ANIMAL EXPERIMENTATION (2013)

Article Neurosciences

Glutamatergic Synapse Formation is Promoted by α7-Containing Nicotinic Acetylcholine Receptors

Adrian F. Lozada et al.

JOURNAL OF NEUROSCIENCE (2012)

Article Biochemistry & Molecular Biology

Chronic exposure to imidacloprid induces inflammation and oxidative stress in the liver & central nervous system of rats

Vesile Duzguner et al.

PESTICIDE BIOCHEMISTRY AND PHYSIOLOGY (2012)

Article Biochemistry & Molecular Biology

Ryanodine receptor-2 upregulation and nicotine-mediated plasticity

Elena Ziviani et al.

EMBO JOURNAL (2011)

Article Agriculture, Multidisciplinary

Overview of the Status and Global Strategy for Neonicotinoids

Peter Jeschke et al.

JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY (2011)

Article Biochemistry & Molecular Biology

Additional Acetylcholine (ACh) Binding Site at α4/α4 Interface of (α4β2)2α4 Nicotinic Receptor Influences Agonist Sensitivity

Simone Mazzaferro et al.

JOURNAL OF BIOLOGICAL CHEMISTRY (2011)

Article Biochemistry & Molecular Biology

Rapid, complete and large-scale generation of post-mitotic neurons from the human LUHMES cell line

Diana Scholz et al.

JOURNAL OF NEUROCHEMISTRY (2011)

Article Pharmacology & Pharmacy

Electrophysiological Perspectives on the Therapeutic Use of Nicotinic Acetylcholine Receptor Partial Agonists

Roger L. Papke et al.

JOURNAL OF PHARMACOLOGY AND EXPERIMENTAL THERAPEUTICS (2011)

Review Pharmacology & Pharmacy

α6β2*and α4β2*Nicotinic Acetylcholine Receptors As Drug Targets for Parkinson's Disease

Maryka Quik et al.

PHARMACOLOGICAL REVIEWS (2011)

Article Chemistry, Medicinal

Aldehyde Oxidase: An Enzyme of Emerging Importance in Drug Discovery

David C. Pryde et al.

JOURNAL OF MEDICINAL CHEMISTRY (2010)

Article Pharmacology & Pharmacy

Neurofunctional endpoints assessed in human neuroblastoma SH-SY5Y cells for estimation of acute systemic toxicity

Helena Gustafsson et al.

TOXICOLOGY AND APPLIED PHARMACOLOGY (2010)

Article Pharmacology & Pharmacy

Activation and Desensitization of Nicotinic α7-type Acetylcholine Receptors by Benzylidene Anabaseines and Nicotine

Roger L. Papke et al.

JOURNAL OF PHARMACOLOGY AND EXPERIMENTAL THERAPEUTICS (2009)

Article Pharmacology & Pharmacy

Cytisine-Based Nicotinic Partial Agonists as Novel Antidepressant Compounds

Yann S. Mineur et al.

JOURNAL OF PHARMACOLOGY AND EXPERIMENTAL THERAPEUTICS (2009)

Review Pharmacology & Pharmacy

The dynamic effects of nicotine on the developing brain

Jennifer B. Dwyer et al.

PHARMACOLOGY & THERAPEUTICS (2009)

Review Mathematical & Computational Biology

Simultaneous inference in general parametric models

Torsten Hothorn et al.

BIOMETRICAL JOURNAL (2008)

Article Pharmacology & Pharmacy

Distinct profiles of α7 nAChR positive allosteric modulation revealed by structurally diverse chemotypes

Jens Halvard Gronlien et al.

MOLECULAR PHARMACOLOGY (2007)

Article Multidisciplinary Sciences

Nootropic α7 nicotinic receptor allosteric modulator derived from GABAA receptor modulators

Herman J. Ng et al.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2007)

Review Medicine, General & Internal

Developmental neurotoxicity of industrial chemicals

P. Grandjean et al.

LANCET (2006)

Article Behavioral Sciences

Effects of maternal intravenous nicotine administration on locomotor behavior in pre-weanling rats

Mark G. LeSage et al.

PHARMACOLOGY BIOCHEMISTRY AND BEHAVIOR (2006)

Article Biochemistry & Molecular Biology

Neonicotinoid insecticides display partial and super agonist actions on native insect nicotinic acetylcholine receptors

Laurence A. Brown et al.

JOURNAL OF NEUROCHEMISTRY (2006)

Article Chemistry, Medicinal

Chloropyridinyl neonicotinoid insecticides: Diverse molecular substituents contribute to facile metabolism in mice

Kevin A. Ford et al.

CHEMICAL RESEARCH IN TOXICOLOGY (2006)

Article Neurosciences

Hierarchical control of dopamine neuron-firing patterns by nicotinic receptors

Monica Mameli-Engvall et al.

NEURON (2006)

Review Pharmacology & Pharmacy

Brain nicotinic acetylcholine receptors: native subtypes and their relevance

Cecilia Gotti et al.

TRENDS IN PHARMACOLOGICAL SCIENCES (2006)

Article Biochemistry & Molecular Biology

Phosphorylation and function of alpha 4 beta 2 receptor

Isabel Bermudez et al.

JOURNAL OF MOLECULAR NEUROSCIENCE (2006)

Article Chemistry, Medicinal

Identification of aldehyde oxidase as the neonicotinoid nitroreductase

RA Dick et al.

CHEMICAL RESEARCH IN TOXICOLOGY (2005)

Review Neurosciences

Desensitization of neuronal nicotinic receptors

MW Quick et al.

JOURNAL OF NEUROBIOLOGY (2002)

Article Neurosciences

Nicotine and nicotinic receptors; Relevance to Parkinson's disease

M Quik et al.

NEUROTOXICOLOGY (2002)

Article Pharmacology & Pharmacy

Study of the calcium dynamics of the human α4β2, α3β4 and α1β1γδ nicotinic acetylcholine receptors

S Michelmore et al.

NAUNYN-SCHMIEDEBERGS ARCHIVES OF PHARMACOLOGY (2002)

Article Pharmacology & Pharmacy

Analgesic and toxic effects of neonicotinoid insecticides in mice

M Tomizawa et al.

TOXICOLOGY AND APPLIED PHARMACOLOGY (2001)

Article Agriculture, Multidisciplinary

Neonicotinoid insecticides: Molecular features conferring selectivity for insect versus mammalian nicotinic receptors

M Tomizawa et al.

JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY (2000)

Article Behavioral Sciences

Drugs selective for nicotinic receptor subtypes: a real possibility or a dream?

C Gotti et al.

BEHAVIOURAL BRAIN RESEARCH (2000)