期刊
ARCHIVES OF TOXICOLOGY
卷 95, 期 11, 页码 3449-3458出版社
SPRINGER HEIDELBERG
DOI: 10.1007/s00204-021-03134-9
关键词
AHR; CD38; PARP7; Sirtuins; Infectious and sterile inflammation
类别
资金
- Projekt DEAL
Research on AHR has shifted from exploring toxicity to elucidating physiological functions. Inflammation ranges from homeostasis to stress responses and defense against infection. NAD(+) mediated energy metabolism plays a crucial role in inflammatory responses.
Aryl hydrocarbon receptor (AHR) research has shifted from exploring dioxin toxicity to elucidation of various physiologic AHR functions. Exposure to 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) is known to exert cellular stress-mediated sterile inflammatory responses in exposed human tissues but may be lethal in sensitive species. Inflammation can be thought of as the extreme end of a spectrum ranging from homeostasis to stress responses (sterile inflammation) and to defense against infection (infectious inflammation). Defense against bacterial infection by generation of reactive oxygen species has to be strictly controlled and may use up a considerable amount of energy. NAD(+)-mediated energy metabolism adapts to various inflammatory responses. As examples, the present commentary tries to integrate responses of AHR and NAD(+)-consuming enzymes (PARP7/TiPARP, CD38 and sirtuins) into infectious and stress-induced inflammatory responses, the latter exemplified by nonalcoholic fatty liver disease (NAFLD). TCDD toxicity models in sensitive species provide hints to molecular AHR targets of energy metabolism including gluconeogenesis and glycolysis. AHR research remains challenging and promising.
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