Prevalence and trend of allergen sensitization in patients with a diagnosis of stasis dermatitis referred for patch testing, North American contact dermatitis group data, 2001-2016

Background Few studies explored the relationship between stasis dermatitis (SD) and allergic contact dermatitis (ACD). Objective To examine trends, associations, and clinical relevance of ACD in patients referred for patch testing who had a final SD diagnosis. Methods Retrospective analysis from 2001 to 2016 of 38,723 patients from the North American Contact Dermatitis Group. Results After patch testing, 303 (0.7%) patients were diagnosed with SD; 46.7% had a concomitant diagnosis of ACD. Patients with vs. without a final SD diagnosis had similar proportions of >= 1 positive allergic reaction (59.7% vs. 64.7%; Chi-square, P = 0.0724) but higher odds of allergic reactions to fragrance mix I, bacitracin, quaternium-15, Myroxylon pereirae, benzalkonium chloride, ethyleneurea melamine formaldehyde, diazolidinyl urea, and propylene glycol. The most commonly relevant allergens in patients with final SD diagnosis were fragrance mix I, Myroxylon pereirae, bacitracin, quaternium-15, and formaldehyde. The most common allergen sources were personal care products, topical medications and other health aid products. Conclusion Nearly half of patients with a final SD diagnosis were also diagnosed with ACD, supporting the role of patch testing in select SD patients.

Automated summary

Nearly half of patients with a final diagnosis of SD were also diagnosed with ACD, indicating the importance of patch testing in select SD patients. Patients with a final SD diagnosis had higher odds of allergic reactions to specific allergens compared to those without a final SD diagnosis. The most common relevant allergens in patients with final SD diagnosis were fragrance mix I, Myroxylon pereirae, bacitracin, quaternium-15, and formaldehyde.