期刊
APPLIED ORGANOMETALLIC CHEMISTRY
卷 36, 期 3, 页码 -出版社
WILEY
DOI: 10.1002/aoc.6565
关键词
antimicrobial; antioxidants; Co (III) complexes; cytotoxicity; hydralazine
This study synthesized four cobalt (III) complexes and evaluated their antimicrobial, anticancer, and antioxidant activities. Complex 4 exhibited the highest cytotoxicity against lung carcinoma cells and the best antioxidant activity.
The antimicrobial, anticancer, and antioxidant activities of four cobalt (III) complexes, [CoL2]X (X = ClO4 over bar (1); OAc over bar (2), Cl over bar (3), or NO3 over bar (4) with hydralazine Schiff base derivative (HL), were presented. The structure of the newly synthesized complexes 1 and 2 was confirmed utilizing FTIR, UV-Vis, and NMR (H-1 and C-13) spectroscopy. In addition, single crystal X-ray diffraction was used to approve the structure of complex 1. Based on Hirshfeld analysis, the molecular packing of 1 is controlled by short H(sic)H, O(sic)H, N(sic)H, and H(sic)C(pi) interactions. The results of the X-ray photoelectron spectroscopy (XPS) for the Co (III) complexes revealed the characteristic peaks of Co-2p3/2 and Co-2p1/2 with binding energy differences of 14.85-14.96 which greatly approved that the Co (III) complexes have been assembled successfully. Complex 4 (IC50 = 14.97 +/- 0.59 mu g/ml) has the highest cytotoxicity against lung carcinoma A-549 cell line compared to the rest of the Co (III) complexes and the free ligand as well. Also, complex 4 has the best antioxidant activity with IC50 of 283.4 +/- 12.3 mu g/ml. The free ligand has broad spectrum of antibacterial and antifungal actions, while the studied Co (III) complexes have good antibacterial activity especially the chloride complex 3.
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