A new method for the synthesis of abiraterone drug catalyzed by Pd-NPs@Zn-MOF as efficient reusable catalyst

The present work provides a novel process for the preparation of abiraterone drug in a Suzuki-Miyaura coupling approach by a new heterogeneous palladium catalyst, Pd-NPs@Zn-MOF, which has been synthesized by one-step encapsulation in nanoporous metal-organic framework Zn-MOF under a temperature control program for the first time. Pd-NPs@Zn-MOF were characterized by transmission electron microscopy (TEM), X-Ray powder diffraction (XRD), BET surface area analysis, inductively coupled plasma (ICP)-optical emission spectrometry (OES), and X-ray photoelectron spectroscopy (XPS).

Automated summary

The study introduced a novel approach for the preparation of abiraterone drug using a new heterogeneous palladium catalyst Pd-NPs@Zn-MOF, synthesized by encapsulation in nanoporous metal-organic framework Zn-MOF under temperature control program. The Pd-NPs@Zn-MOF was characterized by various techniques, including TEM, XRD, BET, ICP-OES, and XPS.