4.7 Article

Dietary supplementation with microalgae enhances the zebrafish growth performance by modulating immune status and gut microbiota

期刊

APPLIED MICROBIOLOGY AND BIOTECHNOLOGY
卷 106, 期 2, 页码 773-788

出版社

SPRINGER
DOI: 10.1007/s00253-021-11751-8

关键词

Microalgae; Zebrafish; Growth performance; Immune status; Gut microbiota

资金

  1. National Natural Science Foundation of China [31872608]
  2. National Key Research and Development Project of China [2019YFA0906300, 2020YFA0907304]
  3. Natural Science Foundation of Shandong Province [ZR2019ZD17]
  4. Natural Science Foundation of Shanghai [21ZR1416400]
  5. State Key Laboratory of Bioreactor Engineering

向作者/读者索取更多资源

Microalgae diets have positive effects on the growth, immune status, and intestinal health of zebrafish, and can serve as a source of dietary supplement.
Microalgae are known to be abundant in various habitats around the globe, and are rich in high value-added products such as fatty acids, polysaccharides, proteins, and pigments. Microalgae can be exploited as the basic and primitive food source of aquatic animals. We investigated the effects of dietary supplementation with Schizochytrium sp., Spirulina platensis, Chloroella sorokiniana, Chromochloris zofingiensis, and Dunaliella salina on the growth performance, immune status, and intestinal health of zebrafish (Danio rerio). The results showed that these five microalgae diets could improve the feed conversion rate (FCR), especially the D. salina (FCR = 1.02%) and Schizochytrium sp. (FCR = 1.20%) additive groups. Moreover, the microalgae diets decreased the gene expression level of the pro-inflammatory cytokines IL6, IL8, and IL1 beta at a normal physiological state of the intestine, especially the Schizochytrium sp., S. platensis, and D. salina dietary groups. The expression of neutrophil marker b7r was increased in the C. sorokiniana diet group; after, the zebrafish were challenged with Vibrio anguillarum, improving the ability to resist this disease. We also found that microalgae diets could regulate the gut microbiota of fish as well as increase the relative abundance of probiotics. To further explain, Cetobacterium was significantly enriched in the S. platensis additive group and Stenotrophomonas was higher in the Schizochytrium sp. additive group than in the other groups. Conversely, harmful bacteria Mycoplasma reduced in all tested microalgae diet groups. Our study indicated that these microalgae could serve as a food source supplement and benefit the health of fish.

作者

我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。

评论

主要评分

4.7
评分不足

次要评分

新颖性
-
重要性
-
科学严谨性
-
评价这篇论文

推荐

暂无数据
暂无数据