期刊
ANTIOXIDANTS & REDOX SIGNALING
卷 37, 期 10-12, 页码 679-703出版社
MARY ANN LIEBERT, INC
DOI: 10.1089/ars.2021.0272
关键词
environmental risk factors; external exposome; air pollution; traffic noise exposure; circadian clock; oxidative stress; cardiovascular risk
资金
- Thilo Weckmuller
Risk factors in the environment, such as air pollution and traffic noise, play a significant role in the development of chronic noncommunicable diseases. Recent data suggest that these factors are associated with a higher risk for cardiovascular, metabolic, and mental diseases, mainly through stress hormone signaling, inflammation, and oxidative stress.
Significance: Risk factors in the environment such as air pollution and traffic noise contribute to the development of chronic noncommunicable diseases.Recent Advances: Epidemiological data suggest that air pollution and traffic noise are associated with a higher risk for cardiovascular, metabolic, and mental disease, including hypertension, heart failure, myocardial infarction, diabetes, arrhythmia, stroke, neurodegeneration, depression, and anxiety disorders, mainly by activation of stress hormone signaling, inflammation, and oxidative stress.Critical Issues: We here provide an in-depth review on the impact of the environmental risk factors air pollution and traffic noise exposure (components of the external exposome) on cardiovascular health, with special emphasis on the role of environmentally triggered oxidative stress and dysregulation of the circadian clock. Also, a general introduction on the contribution of circadian rhythms to cardiovascular health and disease as well as a detailed mechanistic discussion of redox regulatory pathways of the circadian clock system is provided.Future Directions: Finally, we discuss the potential of preventive strategies or chrono therapy for cardioprotection.
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