4.7 Article

Reactive Oxygen Species and Their Consequences on the Structure and Function of Mammalian Spermatozoa

期刊

ANTIOXIDANTS & REDOX SIGNALING
卷 37, 期 7-9, 页码 481-500

出版社

MARY ANN LIEBERT, INC
DOI: 10.1089/ars.2021.0235

关键词

ROS; sperm biology; sperm DNA oxidation; sperm genetic and epigenetic damage; antioxidants

向作者/读者索取更多资源

This review explores the relationship between spermatozoa and reactive oxygen species (ROS), highlighting how spermatozoa rely on ROS for maturity but are highly susceptible to oxidative damage. Recent studies have shown the significant impact of oxidative damage on sperm structures and functions, particularly in terms of fertilization and embryonic development. Future research aims to investigate whether pro-oxidative situations can lead to epigenetic changes in spermatozoa.
Significance: Among the 200 or so cell types that comprise mammals, spermatozoa have an ambiguous relationship with the reactive oxygen species (ROS) inherent in the consumption of oxygen that supports aerobic metabolism.Recent Advances: In this review, we shall see that spermatozoa need the action of ROS to reach their structural and functional maturity, but that due to intrinsic unique characteristics, they are, perhaps more than any other cell type, susceptible to oxidative damage. Recent studies have improved our knowledge of how oxidative damage affects sperm structures and functions. The focus of this review will be on how genetic and epigenetic oxidative alterations to spermatozoa can have dramatic unintended consequences in terms of both the support and the suppression of sperm function.Critical Issues: Oxidative stress can have dramatic consequences not only for the spermatozoon itself, but also, and above all, on its primary objective, which is to carry out fertilization and to ensure, in part, that the embryonic development program should lead to a healthy progeny.Future Directions: Sperm oxidative DNA damage largely affects the integrity of the paternal genetic material to such an extent that the oocyte may have difficulties in correcting it. Diagnostic and therapeutic actions should be considered more systematically, especially in men with difficulties to conceive. Research is underway to determine whether the epigenetic information carried by spermatozoa is also subject to changes mediated by pro-oxidative situations.

作者

我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。

评论

主要评分

4.7
评分不足

次要评分

新颖性
-
重要性
-
科学严谨性
-
评价这篇论文

推荐

暂无数据
暂无数据