Review of Therapies using TiO2 Nanomaterials for Increased Anticancer Capability

Recently, Titanium dioxide (TiO2) has been studied as an alternative to treat cancer diseases under different activation therapies. The aim of this review was to describe the effect of TiO2 nanoparticles (NPs) on some cancer cell lines and their interaction with phototherapies such as photodynamic therapy (PDT), photothermal therapy (PTT), sonodynamic therapy (SDT), and ultraviolet therapy (UV) for anticancer treatment. The use of TiO2 combined with PDT, PTT, SDT, or UV has shown a remarkable capacity to enhance the killing of cancer cells through reactive oxygen species formation. Thus, the combination of TiO2 and activation therapies exhibited great potential and could be a viable anticancer treatment strategy. However, more studies on phototherapies in combination with TiO2 and their effects under different experimental conditions (TiO2 concentration, type of cancer cells, and intensity and frequency of therapies) are necessary to guarantee the safe use of this kind of therapy.

Automated summary

Titanium dioxide nanoparticles have shown remarkable potential as a viable anticancer treatment strategy when combined with activation therapies such as photodynamic therapy, photothermal therapy, sonodynamic therapy, and ultraviolet therapy. These therapies enhance the killing of cancer cells through the formation of reactive oxygen species. However, more studies are needed to ensure the safe use of this therapy under different experimental conditions.