期刊
ANNUAL REVIEW OF PHYSIOLOGY
卷 84, 期 -, 页码 331-354出版社
ANNUAL REVIEWS
DOI: 10.1146/annurev-physiol-061121-040127
关键词
-
类别
资金
- NIH/NINDS [NS106138, NS097775]
- NIH/NIA [AG063031, AG062738]
- NIH-NINDS [F30NS096868]
- American Heart Association postdoctoral fellowship [20POST35160001]
- Luso-American Development Foundation [2017/165]
This review synthesizes current knowledge on the control of blood flow in the brain's microvascular zones, including differences in blood flow between different vascular zones and the role of mural cells in blood flow control. However, many unresolved issues remain.
The vast majority of the brain's vascular length is composed of capillaries, where our understanding of blood flow control remains incomplete. This review synthesizes current knowledge on the control of blood flow across microvascular zones by addressing issues with nomenclature and drawing on new developments from in vivo optical imaging and single-cell transcriptomics. Recent studies have highlighted important distinctions in mural cell morphology, gene expression, and contractile dynamics, which can explain observed differences in response to vasoactive mediators between arteriole, transitional, and capillary zones. Smooth muscle cells of arterioles and ensheathing pericytes of the arteriole-capillary transitional zone control large-scale, rapid changes in blood flow. In contrast, capillary pericytes downstream of the transitional zone act on slower and smaller scales and are involved in establishing resting capillary tone and flow heterogeneity. Many unresolved issues remain, including the vasoactive mediators that activate the different pericyte types in vivo, the role of pericyte-endothelial communication in conducting signals from capillaries to arterioles, and how neurological disease affects these mechanisms.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据