期刊
ANNUAL REVIEW OF PHYSIOLOGY
卷 84, 期 -, 页码 485-506出版社
ANNUAL REVIEWS
DOI: 10.1146/annurev-physiol-061121-035930
关键词
Helicobacter pylori; VacA; CagA; host defenses; TRPML1
类别
资金
- Canadian Institute of Health Research operating grant [MOP 437682]
This article discusses how Helicobacter pylori overcomes gastric epithelial host defense responses to promote its long-term survival and establish a chronic infection through the secretion of virulence factors, immune evasion, and manipulation of cellular mechanisms.
The body depends on its physical barriers and innate and adaptive immune responses to defend against the constant assault of potentially harmful microbes. In turn, successful pathogens have evolved unique mechanisms to adapt to the host environment and manipulate host defenses. Helicobacter pylori (Hp), a human gastric pathogen that is acquired in childhood and persists throughout life, is an example of a bacterium that is very successful at remodeling the host-pathogen interface to promote a long-term persistent infection. Using a combination of secreted virulence factors, immune subversion, and manipulation of cellular mechanisms, Hp can colonize and persist in the hostile environment of the human stomach. Here, we review the most recent and relevant information regarding how this successful pathogen overcomes gastric epithelial host defense responses to facilitate its own survival and establish a chronic infection.
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