期刊
ANNUAL REVIEW OF PATHOLOGY-MECHANISMS OF DISEASE
卷 17, 期 -, 页码 387-402出版社
ANNUAL REVIEWS
DOI: 10.1146/annurev-pathol-042320-034052
关键词
precision medicine; LMICs; diagnostics
类别
资金
- National Institutes of Health [UH3CA211139]
- National Cancer Institute [U54CA190146]
Most cancer cases occur in LMICs where the necessary infrastructure for optimal cancer care is lacking. However, examples of novel partnerships and creative solutions suggest that with determination, creativity, persistence, and some luck, precision medicine may be possible in these countries.
Most cancer cases occur in low- and middle-income countries (LMICs). The sophisticated technical and human infrastructure needed for optimal diagnosis, treatment, and monitoring of cancers is difficult enough in affluent countries; it is especially challenging in LMICs. In Western, educated, industrial, rich, democratic countries, there is a growing emphasis on and success with precision medicine, whereby targeted therapy is directed at cancers based on the specific genetic lesions in the cancer. Can such precision approaches be delivered in LMICs? We offer some examples of novel partnerships and creative solutions that suggest that precision medicine may be possible in LMICs given heavy doses of will, creativity, and persistence and a little luck.
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