4.5 Review

Lysophospholipid Mediators in Health and Disease

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Lysolipids in Vascular Development, Biology, and Disease

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Summary: Membrane phospholipid metabolism produces lysophospholipids, which act as ligands for G-protein-coupled receptors influencing various biological processes. Lysophosphatidic acid and S1P are particularly significant in vascular development and cardiovascular diseases, with potential connections to the Wnt pathway. These findings highlight the importance of lysophospholipid signaling in cardiovascular disease and the potential for novel therapeutic strategies.

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Endothelial S1P1 Signaling Counteracts Infarct Expansion in Ischemic Stroke

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Summary: This study explores the role of endothelial cell S1P(1) in the naive and ischemic brain as a potential target for cerebrovascular therapy. Endothelial S1P(1) plays a critical vascular protective role in the mouse brain, sustaining endothelial functions and expanding during ischemia. Disruption of this pathway exacerbates brain injury in ischemic stroke models, highlighting the importance of S1P signaling in maintaining perfusion and microvascular patency in the ischemic penumbra.

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The riddle of the Sphinx: why sphingosine-1-phosphate may help define molecular mechanisms underlying risk stratification for serious COVID-19 infections

Hugh Rosen et al.

Summary: In this study, the researchers explored the association between S1P serum levels and the severity of COVID-19, proposing a new prognostic indicator.

EMBO MOLECULAR MEDICINE (2021)

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Decreased serum level of sphingosine-1-phosphate: a novel predictor of clinical severity in COVID-19

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Summary: The severity of COVID-19 is significantly associated with anemia, lymphocytopenia, and various biochemical markers. Serum S1P level is inversely correlated with COVID-19 severity, and significantly related to CRP, LDH, ferritin, and D-dimer.

EMBO MOLECULAR MEDICINE (2021)

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Development of an On-Tissue Derivatization Method for MALDI Mass Spectrometry Imaging of Bioactive Lipids Containing Phosphate Monoester Using Phos-tag

Taiga Iwama et al.

Summary: The novel on-tissue derivatization method using Phos-tag in combination with MALDI-MSI enables visualization of low-abundance bioactive lipids like LPA and S1P in the brain, providing a simple and optimal way to reveal the spatial localization of these important molecules in tissues.

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Mechanotransduction activates RhoA in the neighbors of apoptotic epithelial cells to apical extrusion

Kinga Duszyc et al.

Summary: Extrusion is the primary response to apoptosis in epithelial cells, involving E-cadherin and RhoA signaling pathways. Mechanical tension-sensitive mechanotransduction activates RhoA specifically in neighboring cells of apoptotic cells, with S1P also playing a crucial role in the process.

CURRENT BIOLOGY (2021)

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Suppressing postcollection lysophosphatidic acid metabolism improves the precision of plasma LPA quantification

Kuniyuki Kano et al.

Summary: The study developed an optimized plasma preparation method to accurately measure LPA concentrations, revealing lower levels of LPA in humans and mice than previously reported. The increased accuracy also allowed for the detection of circadian rhythms in certain LPA species in mouse plasma.

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Sphingosine 1-phosphate: Lipid signaling in pathology and therapy

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Lysophospholipids in laboratory medicine

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Tumor-draining lymph nodes are pivotal in PD-1/PD-L1 checkpoint therapy

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Structural insights into ligand recognition by the lysophosphatidic acid receptor LPA6

Reiya Taniguchi et al.

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Lymphatic endothelial S1P promotes mitochondrial function and survival in naive T cells

Alejandra Mendoza et al.

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Epithelial cell extrusion: Pathways and pathologies

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Sphingosine 1-phosphate and its carrier apolipoprotein M in human sepsis and in Escherichia coli sepsis in baboons

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Emerging biology of sphingosine-1-phosphate: its role in pathogenesis and therapy

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Two disparate ligand-binding sites in the human P2Y1 receptor

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A map of the distribution of sphingosine 1-phosphate in the spleen

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Lysophosphatidic acid receptor (LPAR) modulators: The current pharmacological toolbox

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Exit Strategies: S1P Signaling and T Cell Migration

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Targeting autocrine HB-EGF signaling with specific ADAM12 inhibition using recombinant ADAM12 prodomain

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Possible Involvement of Minor Lysophospholipids in the Increase in Plasma Lysophosphatidic Acid in Acute Coronary Syndrome

Makoto Kurano et al.

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Host endothelial S1PR1 regulation of vascular permeability modulates tumor growth

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Molecular and physiological functions of sphingosine 1-phosphate transporters

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Lysophospholipid receptor nomenclature review: IUPHAR Review 8

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Design of anticancer lysophosphatidic acid agonists and antagonists

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Sphingosine-1-phosphate receptor 1 reporter mice reveal receptor activation sites in vivo

Mari Kono et al.

JOURNAL OF CLINICAL INVESTIGATION (2014)

Article Biochemistry & Molecular Biology

Separation and quantification of 2-acyl-1-lysophospholipids and 1-acyl-2-lysophospholipids in biological samples by LC-MS/MS

Michiyo Okudaira et al.

JOURNAL OF LIPID RESEARCH (2014)

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Novel lysophosphoplipid receptors: their structure and function

Kumiko Makide et al.

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Diversity and function of membrane glycerophospholipids generated by the remodeling pathway in mammalian cells

Daisuke Hishikawa et al.

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Article Biochemistry & Molecular Biology

Challenges in accurate quantitation of lysophosphatidic acids in human biofluids

Joelle M. Onorato et al.

JOURNAL OF LIPID RESEARCH (2014)

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Lipid landscapes and pipelines in membrane homeostasis

Joost C. M. Holthuis et al.

NATURE (2014)

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Structure of the human P2Y12 receptor in complex with an antithrombotic drug

Kaihua Zhang et al.

NATURE (2014)

Review Multidisciplinary Sciences

Sphingolipid metabolites in inflammatory disease

Michael Maceyka et al.

NATURE (2014)

Article Biochemistry & Molecular Biology

Lysophosphatidic Acid Receptor-2 Deficiency Confers Protection against Bleomycin-Induced Lung Injury and Fibrosis in Mice

Long Shuang Huang et al.

AMERICAN JOURNAL OF RESPIRATORY CELL AND MOLECULAR BIOLOGY (2013)

Article Chemistry, Medicinal

Phosphorothioate analogs of sn-2 radyl lysophosphatidic acid (LPA): Metabolically stabilized LPA receptor agonists

Guowei Jiang et al.

BIOORGANIC & MEDICINAL CHEMISTRY LETTERS (2013)

Review Medical Laboratory Technology

Autotaxin in liver fibrosis

Hitoshi Ikeda et al.

CLINICA CHIMICA ACTA (2012)

Article Medical Laboratory Technology

Increased circulating plasma lysophosphatidic acid in patients with acute coronary syndrome

Tomotaka Dohi et al.

CLINICA CHIMICA ACTA (2012)

Article Cell Biology

Flow-Regulated Endothelial S1P Receptor-1 Signaling Sustains Vascular Development

Bongnam Jung et al.

DEVELOPMENTAL CELL (2012)

Article Biochemical Research Methods

TGFα shedding assay: an accurate and versatile method for detecting GPCR activation

Asuka Inoue et al.

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Stromal epigenetic dysregulation is sufficient to initiate mouse prostate cancer via paracrine Wnt signaling

Yang Zong et al.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2012)

Article Biochemistry & Molecular Biology

LPA-producing enzyme PA-PLA1α regulates hair follicle development by modulating EGFR signalling

Asuka Inoue et al.

EMBO JOURNAL (2011)

Article Chemistry, Analytical

Quantitative determination of lysophosphatidic acids (LPAs) in human saliva and gingival crevicular fluid (GCF) by LC-MS/MS

S. P. Bathena et al.

JOURNAL OF PHARMACEUTICAL AND BIOMEDICAL ANALYSIS (2011)

Article Biochemistry & Molecular Biology

Coordinated interactions between actin and microtubules through crosslinkers in neurite retraction induced by lysophosphatidic acid

Nobuyuki Fukushima et al.

NEUROCHEMISTRY INTERNATIONAL (2011)

Article Medicine, General & Internal

Inflammatory Skin and Bowel Disease Linked to ADAM17 Deletion

Diana C. Blaydon et al.

NEW ENGLAND JOURNAL OF MEDICINE (2011)

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Lysophosphatidic Acid Signaling May Initiate Fetal Hydrocephalus

Yun C. Yung et al.

SCIENCE TRANSLATIONAL MEDICINE (2011)

Article Medicine, Research & Experimental

Sphingosine kinase 1 and sphingosine-1-phosphate receptor 2 are vital to recovery from anaphylactic shock in mice

Ana Olivera et al.

JOURNAL OF CLINICAL INVESTIGATION (2010)

Article Biochemistry & Molecular Biology

Blood sphingolipidomics in healthy humans: impact of sample collection methodology

Samar M. Hammad et al.

JOURNAL OF LIPID RESEARCH (2010)

Review Biochemistry & Molecular Biology

Sphingosine 1-Phosphate Receptor Signaling

Hugh Rosen et al.

ANNUAL REVIEW OF BIOCHEMISTRY (2009)

Article Biochemistry & Molecular Biology

Identification and Characterization of a Novel Lysophosphatidic Acid Receptor, p2y5/LPA6

Keisuke Yanagida et al.

JOURNAL OF BIOLOGICAL CHEMISTRY (2009)

Letter Dermatology

Mutations in the LIPH gene in three Japanese families with autosomal recessive woolly hair/hypotrichosis

Yutaka Shimomura et al.

JOURNAL OF DERMATOLOGICAL SCIENCE (2009)

Article Biochemistry & Molecular Biology

Lipid phosphate phosphatases and signaling

David N. Brindley et al.

JOURNAL OF LIPID RESEARCH (2009)

Article Cardiac & Cardiovascular Systems

Vascular endothelium as a contributor of plasma sphingosine 1-phosphate

Krishnan Venkataraman et al.

CIRCULATION RESEARCH (2008)

Review Biochemistry & Molecular Biology

LPA and its Analogs-Attractive Tools for Elucidation of LPA Biology and Drug Development

Kuniyuki Kano et al.

CURRENT MEDICINAL CHEMISTRY (2008)

Article Genetics & Heredity

G protein-coupled receptor P2Y5 and its ligand LPA are involved in maintenance of human hair growth

Sandra M. Pasternack et al.

NATURE GENETICS (2008)

Article Multidisciplinary Sciences

Human hair growth deficiency is linked to a genetic defect in the phospholipase gene LIPH

Anastasiya Kazantseva et al.

SCIENCE (2006)

Article Biochemistry & Molecular Biology

Autotaxin stabilizes blood vessels and is required for embryonic vasculature by producing lysophosphatidic acid

Masayuki Tanaka et al.

JOURNAL OF BIOLOGICAL CHEMISTRY (2006)

Article Biochemistry & Molecular Biology

GPR92 as a new G12/13- and Gq-coupled lysophosphatidic acid receptor that increases cAMP, LPA5

Chang-Wook Lee et al.

JOURNAL OF BIOLOGICAL CHEMISTRY (2006)

Article Multidisciplinary Sciences

Essential role for Gα13 in endothelial cells during embryonic development

KM Ruppel et al.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2005)

Article Biochemistry & Molecular Biology

Lysophosphatidic acid and autotaxin stimulate cell motility of neoplastic and non-neoplastic cells through LPA1

K Hama et al.

JOURNAL OF BIOLOGICAL CHEMISTRY (2004)

Review Biochemistry & Molecular Biology

The ins and outs of lysophosphatidic acid signaling

WH Moolenaar et al.

BIOESSAYS (2004)

Article Biochemistry & Molecular Biology

Prostatic acid phosphatase degrades lysophosphatidic acid in seminal plasma

M Tanaka et al.

FEBS LETTERS (2004)

Article Biochemistry & Molecular Biology

Initiation of neuropathic pain requires lysophosphatidic acid receptor signaling

M Inoue et al.

NATURE MEDICINE (2004)

Article Neurosciences

LPA1 receptor-deficient mice have phenotypic changes observed in psychiatric disease

SM Harrison et al.

MOLECULAR AND CELLULAR NEUROSCIENCE (2003)

Article Multidisciplinary Sciences

Identification of an intracellular receptor for lysophosphatidic acid (LPA):: LPA is a transcellular PPARγ agonist

TM McIntyre et al.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2003)

Article Biochemistry & Molecular Biology

Serum lysophosphatidic acid is produced through diverse phospholipase pathways

J Aoki et al.

JOURNAL OF BIOLOGICAL CHEMISTRY (2002)

Article Biochemistry & Molecular Biology

Lysophosphatidic acid, a growth factor-like lipid, in the saliva

T Sugiura et al.

JOURNAL OF LIPID RESEARCH (2002)

Article Biochemistry & Molecular Biology

A novel phosphatidic acid-selective phospholipase A1 that produces lysophosphatidic acid

H Sonoda et al.

JOURNAL OF BIOLOGICAL CHEMISTRY (2002)

Article Biochemistry & Molecular Biology

Platelet-activating factor receptor

S Ishii et al.

PROSTAGLANDINS & OTHER LIPID MEDIATORS (2002)

Review Biochemistry & Molecular Biology

Lysophospholipids and the cardiovascular system

JS Karliner

BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR AND CELL BIOLOGY OF LIPIDS (2002)

Review Biochemistry & Molecular Biology

Lysophospholipid regulation of mononuclear phagocytes

H Lee et al.

BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR AND CELL BIOLOGY OF LIPIDS (2002)

Article Biochemistry & Molecular Biology

Plasmalogens, phospholipase A2, and docosahexaenoic acid turnover in brain tissue

AA Farooqui et al.

JOURNAL OF MOLECULAR NEUROSCIENCE (2001)

Article Multidisciplinary Sciences

Requirement for the IpA1 lysophosphatidic acid receptor gene in normal suckling behavior

JJA Contos et al.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2000)