Progress in the Management of Pancreatic Neuroendocrine Tumors

Pancreatic neuroendocrine tumors (PNETs) are a heterogeneous and orphan group of neoplasms that vary in their histology, clinical features, prognosis, and management. The treatment of PNETs is highly dependent on the stage at presentation, tumor grade and differentiation, presence of symptoms from hormonal overproduction or from local growth, tumor burden, and rate of progression. The US Food and Drug Administration has recently approved many novel treatments, which have altered decision making and positively impacted the care and prognosis of these patients. In this review, we focus on the significant progress made in the management of PNETs over the past decade, as well as the active areas of research.

Automated summary

Pancreatic neuroendocrine tumors (PNETs) are a heterogeneous group of neoplasms with varying treatment options. The treatment approach depends on factors such as tumor stage, grade and differentiation, symptoms, tumor burden, and rate of progression. Recent advancements in treatment have positively impacted patient care and prognosis.