期刊
ANNUAL REVIEW OF IMMUNOLOGY
卷 40, 期 -, 页码 15-43出版社
ANNUAL REVIEWS
DOI: 10.1146/annurev-immunol-101320-124243
关键词
IL-33; tissue repair; homeostasis; type 2 immunity; damage-associated molecular patterns; cytokines
类别
资金
- NIH [R01AR073527, R01HL22489, R56AI139327, T32CA082084, F30AI147437, 1R03AI151545]
- Carla Forsythe
Our understanding of the functions of IL-33 in homeostasis and immunity is constantly evolving. IL-33 plays a crucial role in both regulation and the development of inflammatory diseases. It directs a network of key cells that are involved in tissue development, homeostasis, and repair.
Our understanding of the functions of the IL-1 superfamily cytokine and damage-associated molecular pattern IL-33 continues to evolve with our understanding of homeostasis and immunity. The early findings that IL-33 is a potent driver of type 2 immune responses promoting parasite expulsion, but also inflammatory diseases like allergy and asthma, have been further supported. Yet, as the importance of a type 2 response in tissue repair and homeostasis has emerged, so has the fundamental importance of IL-33 to these processes. In this review, we outline an evolving understanding of IL-33 immunobiology, paying particular attention to how IL-33 directs a network of ST2(+) regulatory T cells, reparative and regulatory macrophages, and type 2 innate lymphoid cells that are fundamental to tissue development, homeostasis, and repair.
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