期刊
ANNUAL REVIEW OF IMMUNOLOGY
卷 40, 期 -, 页码 143-167出版社
ANNUAL REVIEWS
DOI: 10.1146/annurev-immunol-101320-014237
关键词
microbiome; neuroimmune; microglia; microbiota; brain; neuroinflammation
类别
The gut microbiome has a significant impact on various physiological functions of the host, particularly in regulating central nervous system homeostasis. Dysbiosis of the gut microbiome and dysregulated neuroimmune responses are common comorbidities of neurodevelopmental, neuropsychiatric, and neurological disorders.
The gut microbiome influences many host physiologies, spanning gastrointestinal function, metabolism, immune homeostasis, neuroactivity, and behavior. Many microbial effects on the host are orchestrated by bidirectional interactions between the microbiome and immune system. Imbalances in this dialogue can lead to immune dysfunction and immune-mediated conditions in distal organs including the brain. Dysbiosis of the gut microbiome and dysregulated neuroimmune responses are common comorbidities of neurodevelopmental, neuropsychiatric, and neurological disorders, highlighting the importance of the gut microbiome-neuroimmune axis as a regulator of central nervous system homeostasis. In this review, we discuss recent evidence supporting a role for the gut microbiome in regulating the neuroimmune landscape in health and disease.
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