期刊
ANNUAL REVIEW OF ECOLOGY, EVOLUTION, AND SYSTEMATICS, VOL 52, 2021
卷 52, 期 -, 页码 177-197出版社
ANNUAL REVIEWS
DOI: 10.1146/annurev-ecolsys-010621-044528
关键词
hitchhiking; genetic recombination; background selection; selective sweeps; Hill-Robertson interference; associative overdominance
资金
- [R35GM139383-01]
Genetic variations and evolution patterns at a given site in a genome are strongly influenced by selection at genetically linked sites, with recombination rates correlating with within-population genetic variability. Different population genetic processes like selective sweeps, background selection, and associative overdominance lead to varying patterns of variability, while interaction between selective and demographic processes significantly impacts variability patterns within genomes.
Patterns of variation and evolution at a given site in a genome can be strongly influenced by the effects of selection at genetically linked sites. In particular, the recombination rates of genomic regions correlate with their amount of within-population genetic variability, the degree to which the frequency distributions of DNA sequence variants differ from their neutral expectations, and the levels of adaptation of their functional components. We review the major population genetic processes that are thought to lead to these patterns, focusing on their effects on patterns of variability: selective sweeps, background selection, associative overdominance, and Hill-Robertson interference among deleterious mutations. We emphasize the difficulties in distinguishing among the footprints of these processes and disentangling them from the effects of purely demographic factors such as population size changes. We also discuss how interactions between selective and demographic processes can significantly affect patterns of variability within genomes.
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