期刊
ANNALS OF THORACIC SURGERY
卷 114, 期 3, 页码 676-682出版社
ELSEVIER SCIENCE INC
DOI: 10.1016/j.athoracsur.2022.01.042
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-
资金
- Health Resources and Services Administration [234-2005-37011C]
The wide adoption of donation after circulatory death (DCD) heart transplantation could lead to a substantial increase in the donor pool size, with approximately 580 additional organs becoming available each year across the United States. This would represent the largest increase in the donor pool in the modern era of heart transplantation.
BACKGROUND the incidence of organ donation after circulatory death (DCD) is increasing; however, heart use has lagged behind other solid organs. Ex vivo perfusion devices are under United States Food and Drug Administration review for use in DCD heart recovery. This study sought to measure the potential increase in the donor pool if DCD heart donation becomes widely adopted. METHODS DCD donor data were obtained from Organ Procurement and Transplantation Network database. Selection criteria included donor age 18 to 49 years, donors meeting Maastricht III criteria, warm ischemia time 30 pound minutes, and donation between 2015 and 2020. Exclusion criteria were coronary disease, prior myocardial infarction, ejection fraction <0.50, significant valve disease, bacteremia, pulmonary capillary wedge pressure >15 mm Hg, and history of HIV/ hepatitis C virus infections.RESULTS There were 12813 DCD donors during this period, of which 3528 met study criteria, and 70 hearts (2%) were transplanted. The use of DCD hearts would represent an additional 48 heart transplants per month, which corresponds to a 21% (3458 of 16521) increase across the country. Median warm ischemia was 23 minutes, with no difference between hearts that were or were not transplanted (23 vs 22.5 minutes, P [ .97). The frequency with which other organs were successfully transplanted was kidney, 92%; liver, 44%; lung, 7%; intestine, 0%; and pancreas, 2%.CONCLUSIONS Wide adoption of DCD heart transplantation could yield a substantial increase in the donor pool size, with approximately 580 additional organs being available each year across the United States. This would represent the largest increase in the donor pool in the modern era of heart transplantation.
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