☆ 4.7 Letter

Anti-ANP32A antibodies in systemic sclerosis

ANNALS OF THE RHEUMATIC DISEASES (2022)

Cancer in Systemic Sclerosis: Analysis of Antibodies Against Components of the Th/To Complex

Christopher A. Mecoli et al.

Summary: This study aimed to describe the prevalence and clinical characteristics of autoantibodies against components of the Th/To complex in SSc patients and determine if they are associated with cancer. Patients with these antibodies showed a clinical phenotype of limited cutaneous disease and pulmonary involvement, and were less likely to develop cancer within 2 years of SSc onset. The findings suggest that Th/To autoantibodies may have a protective effect against contemporaneous cancer.

ARTHRITIS & RHEUMATOLOGY (2021)

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Review Rheumatology