4.7 Review

Strategies to overcome the side effects of chimeric antigen receptor T cell therapy

相关参考文献

注意:仅列出部分参考文献,下载原文获取全部文献信息。
Article Biotechnology & Applied Microbiology

Development of CAR T Cells Expressing a Suicide Gene Plus a Chimeric Antigen Receptor Targeting Signaling Lymphocytic-Activation Molecule F7

Christina Amatya et al.

Summary: CARs targeting SLAMF7 show promise for MM therapy due to specific expression on MM cells, and CD28-containing CARs exhibit superior anti-tumor activity compared to 4-1BB-containing CARs. Inclusion of a suicide gene in SLAMF7-targeting CAR T cells is prudent to eliminate cells expressing SLAMF7 on normal leukocytes when necessary.

MOLECULAR THERAPY (2021)

Review Biophysics

Taming the beast: CRS and ICANS after CAR T-cell therapy for ALL

Vipul Sheth et al.

Summary: Treatment with CD19 or CD22-targeted CAR-T cells shows promising efficacy in refractory or relapsed ALL patients, but is associated with significant toxicities, including CRS and ICANS. Understanding predictors of toxicity severity and developing strategies to enhance the safety of CAR T-cell therapy are crucial in improving outcomes for ALL patients.

BONE MARROW TRANSPLANTATION (2021)

Review Biotechnology & Applied Microbiology

Lymphodepletion strategies to potentiate adoptive T-cell immunotherapy - what are we doing; where are we going?

Natasha Bechman et al.

Summary: Current clinical experience with adoptive T-cell immunotherapy suggests that intermediate dose fludarabine-based regimens may be the optimal choice for balancing efficacy and safety, although further studies are needed to provide definitive evidence.

EXPERT OPINION ON BIOLOGICAL THERAPY (2021)

Review Infectious Diseases

CAR-T cell therapy and infection: a review

Olivia Bupha-Intr et al.

Summary: Patients undergoing CAR-T cell therapy are at increased risk of infection due to prior immunosuppression and treatment-specific toxicities, highlighting the importance of infection prevention strategies. Ongoing surveillance and effective prophylaxis are essential to support safe and effective patient care in the rapid adoption of CAR-T cell therapy.

EXPERT REVIEW OF ANTI-INFECTIVE THERAPY (2021)

Article Biochemistry & Molecular Biology

Targeting CDK7 suppresses super enhancer-linked inflammatory genes and alleviates CAR T cell-induced cytokine release syndrome

Ye Wei et al.

Summary: Targeting CDK7 has shown potential as a promising strategy for treating CRS by inhibiting multiple cytokines. CDK7 blockade attenuated cytokine release, mitigated hyperinflammatory states, and rescued mice from lethal CRS, without causing tissue injury or impairing antitumor effects. Targeting CDK7 preferentially suppressed a set of inflammatory genes, of which STAT1 and IL1 were identified as key targets associated with super enhancers.

MOLECULAR CANCER (2021)

Review Cell Biology

Manipulating the Metabolism to Improve the Efficacy of CAR T-Cell Immunotherapy

Marsha Pellegrino et al.

Summary: The adoptive transfer of CAR-expressing T cells has shown unprecedented success in treating B-cell malignancies, but its efficacy in other types of cancers is still limited. The metabolic fitness of CAR T cells plays a crucial role in their ability to target and function within solid tumors, with both tumor and T cell metabolism impacting the immune response significantly.
Article Oncology

A metabolic switch to memory CAR T cells: Implications for cancer treatment

Hosein Rostamian et al.

Summary: The therapeutic efficacy of CAR T cells in hematological malignancies is remarkable, but limited in solid tumors due to challenges of persistence and dysfunction in an immunosuppressive tumor microenvironment. Reprogramming CAR T cell metabolism and targeting metabolic pathways can enhance antitumor activity, with strategies focusing on promoting longevity and altering cellular fate within tumors.

CANCER LETTERS (2021)

Review Oncology

Recent advances and discoveries in the mechanisms and functions of CAR T cells

Rebecca C. Larson et al.

Summary: This review summarizes the major advances that have been made in the efficacy and safety of CAR T cell therapies over the past 3 years and looks ahead to new findings that will impact the future of this immunotherapy.

NATURE REVIEWS CANCER (2021)

Review Oncology

Current Progress in CAR-T Cell Therapy for Hematological Malignancies

Donglei Han et al.

Summary: CAR-T cell therapy has shown significant progress in treating hematologic malignancies and is expected to become a mainstream treatment choice in the future. Despite the toxicities and gaps in knowledge, it is anticipated to exhibit superior safety and efficacy in the future.

JOURNAL OF CANCER (2021)

Review Medicine, Research & Experimental

Chimeric antigen receptor -T cell therapy: Applications and challenges in treatment of allergy and asthma

Abdolreza Esmaeilzadeh et al.

BIOMEDICINE & PHARMACOTHERAPY (2020)

Review Biochemistry & Molecular Biology

The Evolving Protein Engineering in the Design of Chimeric Antigen Receptor T Cells

Hannah E. Hughes-Parry et al.

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES (2020)

Review Chemistry, Multidisciplinary

Current challenges and emerging opportunities of CAR-T cell therapies

Teresa R. Abreu et al.

JOURNAL OF CONTROLLED RELEASE (2020)

Article Biotechnology & Applied Microbiology

A computationally designed chimeric antigen receptor provides a small-molecule safety switch for T-cell therapy

Greta Giordano-Attianese et al.

NATURE BIOTECHNOLOGY (2020)

Review Oncology

Engineering strategies to overcome the current roadblocks in CAR T cell therapy

Sarwish Rafiq et al.

NATURE REVIEWS CLINICAL ONCOLOGY (2020)

Review Oncology

Dual Targeting to Overcome Current Challenges in Multiple Myeloma CAR T-Cell Treatment

Jort J. van der Schans et al.

FRONTIERS IN ONCOLOGY (2020)

Article Critical Care Medicine

Extracorporeal cytokine removal in severe CAR-T cell associated cytokine release syndrome

Klaus Stahl et al.

JOURNAL OF CRITICAL CARE (2020)

Review Oncology

Recent advances in CAR-T cell engineering

Ruihao Huang et al.

JOURNAL OF HEMATOLOGY & ONCOLOGY (2020)

Review Biochemical Research Methods

All systems go: converging synthetic biology and combinatorial treatment for CAR-T cell therapy

Evripidis Lanitis et al.

CURRENT OPINION IN BIOTECHNOLOGY (2020)

News Item Medicine, General & Internal

CAR-T Therapy Is Approved for Mantle Cell Lymphoma

Rebecca Voelker

JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION (2020)

Article Cardiac & Cardiovascular Systems

CAR T Cell and BiTE Therapy-New Therapies, New Risks?

Daniel H. Chen et al.

CURRENT CARDIOVASCULAR RISK REPORTS (2020)

Review Oncology

Management guidelines for paediatric patients receiving chimeric antigen receptor T cell therapy

Kris M. Mahadeo et al.

NATURE REVIEWS CLINICAL ONCOLOGY (2019)

Review Biochemistry & Molecular Biology

Killing Mechanisms of Chimeric Antigen Receptor (CAR) T Cells

Mohamed-Reda Benmebarek et al.

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES (2019)

Article Oncology

CAR T-Cell Associated Neurotoxicity: Mechanisms, Clinicopathologic Correlates, and Future Directions

Bradley D. Hunter et al.

JNCI-JOURNAL OF THE NATIONAL CANCER INSTITUTE (2019)

Article Biotechnology & Applied Microbiology

CRISPR/Cas9-based genome editing in the era of CAR T cell immunotherapy

January Salas-Mckee et al.

HUMAN VACCINES & IMMUNOTHERAPEUTICS (2019)

Review Oncology

Multi Targeted CAR-T Cell Therapies for B-Cell Malignancies

Nirav N. Shah et al.

FRONTIERS IN ONCOLOGY (2019)

Review Oncology

The Emergence of Universal Immune Receptor T Cell Therapy for Cancer

Nicholas G. Minutolo et al.

FRONTIERS IN ONCOLOGY (2019)

Article Hematology

Improving the safety of CAR-T cell therapy by controlling CRS-related coagulopathy

Huiwen Jiang et al.

ANNALS OF HEMATOLOGY (2019)

Article Biotechnology & Applied Microbiology

Modulation of chimeric antigen receptor surface expression by a small molecule switch

Alexandre Juillerat et al.

BMC BIOTECHNOLOGY (2019)

Review Immunology

Tocilizumab for the treatment of chimeric antigen receptor T cell-induced cytokine release syndrome

Chelsea Kotch et al.

EXPERT REVIEW OF CLINICAL IMMUNOLOGY (2019)

Article Oncology

Managing the toxicities of CAR T-cell therapy

Sattva S. Neelapu

HEMATOLOGICAL ONCOLOGY (2019)

Review Immunology

Cellular therapy: Immune-related complications

Joseph H. Oved et al.

IMMUNOLOGICAL REVIEWS (2019)

Review Oncology

Engineering switchable and programmable universal CARs for CAR T therapy

Delong Liu et al.

JOURNAL OF HEMATOLOGY & ONCOLOGY (2019)

Article Cell Biology

The tyrosine kinase inhibitor dasatinib acts as a pharmacologic on/off switch for CAR T cells

Katrin Mestermann et al.

SCIENCE TRANSLATIONAL MEDICINE (2019)

Review Biochemistry & Molecular Biology

Next generation chimeric antigen receptor T cells: safety strategies to overcome toxicity

Shengnan Yu et al.

MOLECULAR CANCER (2019)

Review Hematology

Allogeneic CAR T cell therapies for leukemia

Waseem Qasim

AMERICAN JOURNAL OF HEMATOLOGY (2019)

Letter Oncology

Stuttering as the first sign of CAR-T-cell-related encephalopathy syndrome (CRES)

L. Nicolas Gonzalez Castro et al.

JOURNAL OF CANCER RESEARCH AND CLINICAL ONCOLOGY (2019)

Article Oncology

Two-Dimensional Regulation of CAR-T Cell Therapy with Orthogonal Switches

Mylinh T. Duong et al.

MOLECULAR THERAPY-ONCOLYTICS (2019)

Article Biochemistry & Molecular Biology

Adoptive immunotherapy with CAR modified T cells in cancer: current landscape and future perspectives

Marta Coscia et al.

FRONTIERS IN BIOSCIENCE-LANDMARK (2019)

Review Hematology

CAR T Cell Toxicity: Current Management and Future Directions

Lucrecia Yanez et al.

HEMASPHERE (2019)

Review Oncology

Chimeric antigen receptor T-cell therapy - assessment and management of toxicities

Sattva S. Neelapu et al.

NATURE REVIEWS CLINICAL ONCOLOGY (2018)

Article Biochemistry & Molecular Biology

Universal Chimeric Antigen Receptors for Multiplexed and Logical Control of T Cell Responses

Jang Hwan Cho et al.

Review Oncology

Antigenic targets of CAR T Cell Therapy. A retrospective view on clinical trials

Fatemeh Arabi et al.

EXPERIMENTAL CELL RESEARCH (2018)

Review Biotechnology & Applied Microbiology

Strategies for enhancing adoptive T-cell immunotherapy against solid tumors using engineered cytokine signaling and other modalities

Thomas Shum et al.

EXPERT OPINION ON BIOLOGICAL THERAPY (2018)

Editorial Material Biochemistry & Molecular Biology

Fludarabine and neurotoxicity in engineered T-cell therapy

Kate L. Lowe et al.

GENE THERAPY (2018)

Review Oncology

Grading of cytokine release syndrome associated with the CAR T cell therapy tisagenlecleucel

David Porter et al.

JOURNAL OF HEMATOLOGY & ONCOLOGY (2018)

Article Biotechnology & Applied Microbiology

Dominant-Negative TGF-β Receptor Enhances PSMA-Targeted Human CAR T Cell Proliferation And Augments Prostate Cancer Eradication

Christopher C. Kloss et al.

MOLECULAR THERAPY (2018)

Article Biotechnology & Applied Microbiology

IL-7 and CCL19 expression in CAR-T cells improves immune cell infiltration and CAR-T cell survival in the tumor

Keishi Adachi et al.

NATURE BIOTECHNOLOGY (2018)

Article Biochemistry & Molecular Biology

CAR T cell-induced cytokine release syndrome is mediated by macrophages and abated by IL-1 blockade

Theodoros Giavridis et al.

NATURE MEDICINE (2018)

Editorial Material Biotechnology & Applied Microbiology

The market for chimeric antigen receptor T cell therapies

Amy Yip et al.

NATURE REVIEWS DRUG DISCOVERY (2018)

Review Multidisciplinary Sciences

CAR T cell immunotherapy for human cancer

Carl H. June et al.

SCIENCE (2018)

Review Engineering, Biomedical

Programming CAR-T cells to kill cancer

Louai Labanieh et al.

NATURE BIOMEDICAL ENGINEERING (2018)

Article Biotechnology & Applied Microbiology

Targeted delivery of a PD-1-blocking scFv by CAR-T cells enhances anti-tumor efficacy in vivo

Sarwish Rafiq et al.

NATURE BIOTECHNOLOGY (2018)

Review Oncology

Tumor Antigen Escape from CAR T-cell Therapy

Robbie G. Majzner et al.

CANCER DISCOVERY (2018)

Article

Cytokine Release Syndrome with Chimeric Antigen Receptor T Cell Therapy

Noelle Frey et al.

BIOLOGY OF BLOOD AND MARROW TRANSPLANTATION (2018)

Review Oncology

Universal CARs, universal T cells, and universal CAR T cells

Juanjuan Zhao et al.

JOURNAL OF HEMATOLOGY & ONCOLOGY (2018)

Article Multidisciplinary Sciences

Switchable control over in vivo CAR T expansion, B cell depletion, and induction of memory

Sophie Viaud et al.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2018)

Review Immunology

Making CAR T Cells a Solid Option for Solid Tumors

Andrea Schmidts et al.

FRONTIERS IN IMMUNOLOGY (2018)

Review Immunology

Engineering CAR-T Cells for Improved Function Against Solid Tumors

Michael A. Morgan et al.

FRONTIERS IN IMMUNOLOGY (2018)

Article Immunology

Synthetic immune niches for cancer immunotherapy

Jorieke Weiden et al.

NATURE REVIEWS IMMUNOLOGY (2018)

Review Immunology

CAR T cells for infection, autoimmunity and allotransplantation

Colby R. Maldini et al.

NATURE REVIEWS IMMUNOLOGY (2018)

Letter Cell Biology

CRISPR-Cas9-mediated multiplex gene editing in CAR-T cells

Xiaojuan Liu et al.

CELL RESEARCH (2017)

Review Cell Biology

CAR T-cell therapy of solid tumors

Carmen S. M. Yong et al.

IMMUNOLOGY AND CELL BIOLOGY (2017)

Review Oncology

New development in CAR-T cell therapy

Zhenguang Wang et al.

JOURNAL OF HEMATOLOGY & ONCOLOGY (2017)

Review Oncology

A new insight in chimeric antigen receptor-engineered T cells for cancer immunotherapy

Erhao Zhang et al.

JOURNAL OF HEMATOLOGY & ONCOLOGY (2017)

Article Biotechnology & Applied Microbiology

Integration of a CD19 CAR into the. TCR Alpha Chain Locus Streamlines Production of Allogeneic Gene-Edited CAR T Cells

Daniel T. MacLeod et al.

MOLECULAR THERAPY (2017)

Article Biotechnology & Applied Microbiology

Avoidance of On-Target Off-Tumor Activation Using a Co-stimulation-Only Chimeric Antigen Receptor

Jonathan Fisher et al.

MOLECULAR THERAPY (2017)

Article Multidisciplinary Sciences

Targeting a CAR to the TRAC locus with CRISPR/Cas9 enhances tumour rejection

Justin Eyquem et al.

NATURE (2017)

News Item Biotechnology & Applied Microbiology

CAR T therapies drive into new terrain

Katie Kingwell

NATURE REVIEWS DRUG DISCOVERY (2017)

Review Pharmacology & Pharmacy

Development of CAR T cells designed to improve antitumor efficacy and safety

Janneke E. Jaspers et al.

PHARMACOLOGY & THERAPEUTICS (2017)

Article Multidisciplinary Sciences

An oxygen sensitive self-decision making engineered CAR T-cell

Alexandre Juillerat et al.

SCIENTIFIC REPORTS (2017)

Article Multidisciplinary Sciences

Armored CAR T cells enhance antitumor efficacy and overcome the tumor microenvironment

Oladapo O. Yeku et al.

SCIENTIFIC REPORTS (2017)

Review Medicine, Research & Experimental

Global Manufacturing of CAR T Cell Therapy

Bruce L. Levine et al.

MOLECULAR THERAPY-METHODS & CLINICAL DEVELOPMENT (2017)

Review Oncology

Tumor Lysis Syndrome in Patients with Hematological Malignancies

Yohannes Belay et al.

JOURNAL OF ONCOLOGY (2017)

Review Medicine, Research & Experimental

Clinical development of CAR T cells-challenges and opportunities in translating innovative treatment concepts

Jessica Hartmann et al.

EMBO MOLECULAR MEDICINE (2017)

Review Oncology

Engineering CAR-T cells

Cheng Zhang et al.

BIOMARKER RESEARCH (2017)

Article Medicine, Research & Experimental

Human CAR T cells with cell-intrinsic PD-1 checkpoint blockade resist tumor-mediated inhibition

Leonid Cherkassky et al.

JOURNAL OF CLINICAL INVESTIGATION (2016)

Article Medicine, Research & Experimental

Dual CD19 and CD123 targeting prevents antigen-loss relapses after CD19-directed immunotherapies

Marco Ruella et al.

JOURNAL OF CLINICAL INVESTIGATION (2016)

Article Multidisciplinary Sciences

In vivo genome editing via CRISPR/Cas9 mediated homology-independent targeted integration

Keiichiro Suzuki et al.

NATURE (2016)

Article Multidisciplinary Sciences

Versatile strategy for controlling the specificity and activity of engineered T cells

Jennifer S. Y. Ma et al.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2016)

Article Multidisciplinary Sciences

Switch-mediated activation and retargeting of CAR-T cells for B-cell malignancies

David T. Rodgers et al.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2016)

Review Immunology

Chimeric antigen receptor-redirected T cells return to the bench

Claudia Geldres et al.

SEMINARS IN IMMUNOLOGY (2016)

Editorial Material Hematology

Medical management of side effects related to CAR T cell therapy in hematologic malignancies

Manjusha Namuduri et al.

EXPERT REVIEW OF HEMATOLOGY (2016)

Review Immunology

CAR T Cell Therapy: A Game Changer in Cancer Treatment

Hilde Almasbak et al.

JOURNAL OF IMMUNOLOGY RESEARCH (2016)

Review Oncology

CAR models: next-generation CAR modifications for enhanced T-cell function

Daniel Abate-Daga et al.

MOLECULAR THERAPY-ONCOLYTICS (2016)

Review Oncology

Toxicity and management in CAR T-cell therapy

Challice L. Bonifant et al.

MOLECULAR THERAPY-ONCOLYTICS (2016)

Article Biotechnology & Applied Microbiology

Redesigned Escherichia coli cytosine deaminase: a new facet of suicide gene therapy

Asif Raza et al.

JOURNAL OF GENE MEDICINE (2015)

Review Immunology

Engineering CAR-T cells: Design concepts

Shivani Srivastava et al.

TRENDS IN IMMUNOLOGY (2015)

Article Biotechnology & Applied Microbiology

Reversal of Tumor Immune Inhibition Using a Chimeric Cytokine Receptor

Ann M. Leen et al.

MOLECULAR THERAPY (2014)

Article Medicine, General & Internal

Chimeric Antigen Receptor T Cells for Sustained Remissions in Leukemia

Shannon L. Maude et al.

NEW ENGLAND JOURNAL OF MEDICINE (2014)

Article Cell Biology

Efficacy and Toxicity Management of 19-28z CAR T Cell Therapy in B Cell Acute Lymphoblastic Leukemia

Marco L. Davila et al.

SCIENCE TRANSLATIONAL MEDICINE (2014)

Article Medicine, General & Internal

Chimeric Antigen Receptor-Modified T Cells for Acute Lymphoid Leukemia

Stephan A. Grupp et al.

NEW ENGLAND JOURNAL OF MEDICINE (2013)

Article Multidisciplinary Sciences

RNA-Guided Human Genome Engineering via Cas9

Prashant Mali et al.

SCIENCE (2013)

Article Oncology

T Cells Expressing Chimeric Antigen Receptors Can Cause Anaphylaxis in Humans

Marcela V. Maus et al.

CANCER IMMUNOLOGY RESEARCH (2013)

Article Biotechnology & Applied Microbiology

Comparison of Different Suicide-Gene Strategies for the Safety Improvement of Genetically Manipulated T Cells

Virna Marin et al.

HUMAN GENE THERAPY METHODS (2012)

Article Oncology

Prognostic significance of acute renal injury in acute tumor lysis syndrome

Michael Darmon et al.

LEUKEMIA & LYMPHOMA (2010)

Review Oncology

CAR Mechanics: Driving T Cells into the MUC of Cancer

John Maher et al.

CANCER RESEARCH (2009)

Article Hematology

Retroviral transfer of human CD20 as a suicide gene for adoptive T-cell therapy

Marieke Griffioen et al.

HAEMATOLOGICA-THE HEMATOLOGY JOURNAL (2009)

Article Biotechnology & Applied Microbiology

Rasburicase: future directions in tumor lysis management

Jessica Hochberg et al.

EXPERT OPINION ON BIOLOGICAL THERAPY (2008)

Article Medicine, Research & Experimental

Insertional oncogenesis in 4 patients after retrovirus-mediated gene therapy of SCID-X1

Salima Hacein-Bey-Abina et al.

JOURNAL OF CLINICAL INVESTIGATION (2008)

Article Multidisciplinary Sciences

Retroviral vector integration deregulates gene expression but has no consequence on the biology and function of transplanted T cells

A Recchia et al.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2006)

Article Multidisciplinary Sciences

LMO2-associated clonal T cell proliferation in two patients after gene therapy for SCID-X1

S Hacein-Bey-Abina et al.

SCIENCE (2003)