相关参考文献
注意:仅列出部分参考文献,下载原文获取全部文献信息。Development of CAR T Cells Expressing a Suicide Gene Plus a Chimeric Antigen Receptor Targeting Signaling Lymphocytic-Activation Molecule F7
Christina Amatya et al.
MOLECULAR THERAPY (2021)
Taming the beast: CRS and ICANS after CAR T-cell therapy for ALL
Vipul Sheth et al.
BONE MARROW TRANSPLANTATION (2021)
Lymphodepletion strategies to potentiate adoptive T-cell immunotherapy - what are we doing; where are we going?
Natasha Bechman et al.
EXPERT OPINION ON BIOLOGICAL THERAPY (2021)
CAR-T cell therapy and infection: a review
Olivia Bupha-Intr et al.
EXPERT REVIEW OF ANTI-INFECTIVE THERAPY (2021)
Targeting CDK7 suppresses super enhancer-linked inflammatory genes and alleviates CAR T cell-induced cytokine release syndrome
Ye Wei et al.
MOLECULAR CANCER (2021)
Manipulating the Metabolism to Improve the Efficacy of CAR T-Cell Immunotherapy
Marsha Pellegrino et al.
CELLS (2021)
A metabolic switch to memory CAR T cells: Implications for cancer treatment
Hosein Rostamian et al.
CANCER LETTERS (2021)
Recent advances and discoveries in the mechanisms and functions of CAR T cells
Rebecca C. Larson et al.
NATURE REVIEWS CANCER (2021)
Current Progress in CAR-T Cell Therapy for Hematological Malignancies
Donglei Han et al.
JOURNAL OF CANCER (2021)
Chimeric antigen receptor -T cell therapy: Applications and challenges in treatment of allergy and asthma
Abdolreza Esmaeilzadeh et al.
BIOMEDICINE & PHARMACOTHERAPY (2020)
The Evolving Protein Engineering in the Design of Chimeric Antigen Receptor T Cells
Hannah E. Hughes-Parry et al.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES (2020)
Tumor infiltration and cytokine biomarkers of prostate stem cell antigen (PSCA)-directed GOCAR-T cells in patients with advanced pancreatic tumors.
Joanne Shaw et al.
JOURNAL OF CLINICAL ONCOLOGY (2020)
Current challenges and emerging opportunities of CAR-T cell therapies
Teresa R. Abreu et al.
JOURNAL OF CONTROLLED RELEASE (2020)
A computationally designed chimeric antigen receptor provides a small-molecule safety switch for T-cell therapy
Greta Giordano-Attianese et al.
NATURE BIOTECHNOLOGY (2020)
Engineering strategies to overcome the current roadblocks in CAR T cell therapy
Sarwish Rafiq et al.
NATURE REVIEWS CLINICAL ONCOLOGY (2020)
Adaptor CAR Platforms-Next Generation of T Cell-Based Cancer Immunotherapy
Claudia Arndt et al.
CANCERS (2020)
Dual Targeting to Overcome Current Challenges in Multiple Myeloma CAR T-Cell Treatment
Jort J. van der Schans et al.
FRONTIERS IN ONCOLOGY (2020)
Extracorporeal cytokine removal in severe CAR-T cell associated cytokine release syndrome
Klaus Stahl et al.
JOURNAL OF CRITICAL CARE (2020)
Recent advances in CAR-T cell engineering
Ruihao Huang et al.
JOURNAL OF HEMATOLOGY & ONCOLOGY (2020)
All systems go: converging synthetic biology and combinatorial treatment for CAR-T cell therapy
Evripidis Lanitis et al.
CURRENT OPINION IN BIOTECHNOLOGY (2020)
CAR-T Therapy Is Approved for Mantle Cell Lymphoma
Rebecca Voelker
JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION (2020)
CAR T Cell and BiTE Therapy-New Therapies, New Risks?
Daniel H. Chen et al.
CURRENT CARDIOVASCULAR RISK REPORTS (2020)
Management guidelines for paediatric patients receiving chimeric antigen receptor T cell therapy
Kris M. Mahadeo et al.
NATURE REVIEWS CLINICAL ONCOLOGY (2019)
Clinical presentation, management, and biomarkers of neurotoxicity after adoptive immunotherapy with CAR T cells
Philipp Karschnia et al.
BLOOD (2019)
Killing Mechanisms of Chimeric Antigen Receptor (CAR) T Cells
Mohamed-Reda Benmebarek et al.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES (2019)
CAR T-Cell Associated Neurotoxicity: Mechanisms, Clinicopathologic Correlates, and Future Directions
Bradley D. Hunter et al.
JNCI-JOURNAL OF THE NATIONAL CANCER INSTITUTE (2019)
Combining the best of two worlds: highly flexible chimeric antigen receptor adaptor molecules (CAR-adaptors) for the recruitment of chimeric antigen receptor T cells
Diana Darowski et al.
MABS (2019)
Management of cytokine release syndrome and neurotoxicity in chimeric antigen receptor (CAR) T cell therapy
Utkarsh H. Acharya et al.
EXPERT REVIEW OF HEMATOLOGY (2019)
CRISPR/Cas9-based genome editing in the era of CAR T cell immunotherapy
January Salas-Mckee et al.
HUMAN VACCINES & IMMUNOTHERAPEUTICS (2019)
Multi Targeted CAR-T Cell Therapies for B-Cell Malignancies
Nirav N. Shah et al.
FRONTIERS IN ONCOLOGY (2019)
The Emergence of Universal Immune Receptor T Cell Therapy for Cancer
Nicholas G. Minutolo et al.
FRONTIERS IN ONCOLOGY (2019)
Improving the safety of CAR-T cell therapy by controlling CRS-related coagulopathy
Huiwen Jiang et al.
ANNALS OF HEMATOLOGY (2019)
Immunogenicity of Chimeric Antigen Receptor T-Cell Therapeutics
Boris Gorovits et al.
BIODRUGS (2019)
Modulation of chimeric antigen receptor surface expression by a small molecule switch
Alexandre Juillerat et al.
BMC BIOTECHNOLOGY (2019)
Tocilizumab for the treatment of chimeric antigen receptor T cell-induced cytokine release syndrome
Chelsea Kotch et al.
EXPERT REVIEW OF CLINICAL IMMUNOLOGY (2019)
Managing the toxicities of CAR T-cell therapy
Sattva S. Neelapu
HEMATOLOGICAL ONCOLOGY (2019)
MSKCC EARLY EXPERIENCE USING RADIOTHERAPY AS A BRIDGING STRATEGY FOR RELAPSED DIFFUSE LARGE B CELL LYMPHOMA BEFORE CD19 CAR T THERAPY
B.S. Imber et al.
HEMATOLOGICAL ONCOLOGY (2019)
Cellular therapy: Immune-related complications
Joseph H. Oved et al.
IMMUNOLOGICAL REVIEWS (2019)
The UniCAR system: A modular CAR T cell approach to improve the safety of CAR T cells
Michael Bachmann
IMMUNOLOGY LETTERS (2019)
Engineering switchable and programmable universal CARs for CAR T therapy
Delong Liu et al.
JOURNAL OF HEMATOLOGY & ONCOLOGY (2019)
The tyrosine kinase inhibitor dasatinib acts as a pharmacologic on/off switch for CAR T cells
Katrin Mestermann et al.
SCIENCE TRANSLATIONAL MEDICINE (2019)
Insight into mechanisms associated with cytokine release syndrome and neurotoxicity after CD19 CAR-T cell immunotherapy
Cassie K. Chou et al.
BONE MARROW TRANSPLANTATION (2019)
Conjugated CAR T cell one step beyond conventional CAR T cell for a promising cancer immunotherapy
Shahin Hallaj et al.
CELLULAR IMMUNOLOGY (2019)
Next generation chimeric antigen receptor T cells: safety strategies to overcome toxicity
Shengnan Yu et al.
MOLECULAR CANCER (2019)
Prophylactic Itacitinib (INCB039110) for the Prevention of Cytokine Release Syndrome Induced By Chimeric Antigen Receptor T-Cells (CAR-T-cells) Therapy
Eduardo Huarte et al.
BLOOD (2019)
Allogeneic CAR T cell therapies for leukemia
Waseem Qasim
AMERICAN JOURNAL OF HEMATOLOGY (2019)
Recent advances in CAR T-cell toxicity: Mechanisms, manifestations and management
Jennifer N. Brudno et al.
BLOOD REVIEWS (2019)
Stuttering as the first sign of CAR-T-cell-related encephalopathy syndrome (CRES)
L. Nicolas Gonzalez Castro et al.
JOURNAL OF CANCER RESEARCH AND CLINICAL ONCOLOGY (2019)
Two-Dimensional Regulation of CAR-T Cell Therapy with Orthogonal Switches
Mylinh T. Duong et al.
MOLECULAR THERAPY-ONCOLYTICS (2019)
Adoptive immunotherapy with CAR modified T cells in cancer: current landscape and future perspectives
Marta Coscia et al.
FRONTIERS IN BIOSCIENCE-LANDMARK (2019)
CAR T Cell Toxicity: Current Management and Future Directions
Lucrecia Yanez et al.
HEMASPHERE (2019)
Clonal expansion of CAR T cells harboring lentivector integration in the CBL gene following anti-CD22 CAR T-cell therapy
Nirali N. Shah et al.
BLOOD ADVANCES (2019)
Toll-like receptor 2 costimulation potentiates the antitumor efficacy of CAR T Cells
Y. Lai et al.
LEUKEMIA (2018)
Chimeric antigen receptor T-cell therapy - assessment and management of toxicities
Sattva S. Neelapu et al.
NATURE REVIEWS CLINICAL ONCOLOGY (2018)
Universal Chimeric Antigen Receptors for Multiplexed and Logical Control of T Cell Responses
Jang Hwan Cho et al.
CELL (2018)
Antigenic targets of CAR T Cell Therapy. A retrospective view on clinical trials
Fatemeh Arabi et al.
EXPERIMENTAL CELL RESEARCH (2018)
Strategies for enhancing adoptive T-cell immunotherapy against solid tumors using engineered cytokine signaling and other modalities
Thomas Shum et al.
EXPERT OPINION ON BIOLOGICAL THERAPY (2018)
Fludarabine and neurotoxicity in engineered T-cell therapy
Kate L. Lowe et al.
GENE THERAPY (2018)
Chimeric antigen receptor T cell (CAR-T) immunotherapy for solid tumors: lessons learned and strategies for moving forward
Jian Li et al.
JOURNAL OF HEMATOLOGY & ONCOLOGY (2018)
Grading of cytokine release syndrome associated with the CAR T cell therapy tisagenlecleucel
David Porter et al.
JOURNAL OF HEMATOLOGY & ONCOLOGY (2018)
Dominant-Negative TGF-β Receptor Enhances PSMA-Targeted Human CAR T Cell Proliferation And Augments Prostate Cancer Eradication
Christopher C. Kloss et al.
MOLECULAR THERAPY (2018)
IL-7 and CCL19 expression in CAR-T cells improves immune cell infiltration and CAR-T cell survival in the tumor
Keishi Adachi et al.
NATURE BIOTECHNOLOGY (2018)
Monocyte-derived IL-1 and IL-6 are differentially required for cytokine-release syndrome and neurotoxicity due to CAR T cells
Margherita Norelli et al.
NATURE MEDICINE (2018)
Determinants of response and resistance to CD19 chimeric antigen receptor (CAR) T cell therapy of chronic lymphocytic leukemia
Joseph A. Fraietta et al.
NATURE MEDICINE (2018)
CAR T cell-induced cytokine release syndrome is mediated by macrophages and abated by IL-1 blockade
Theodoros Giavridis et al.
NATURE MEDICINE (2018)
The market for chimeric antigen receptor T cell therapies
Amy Yip et al.
NATURE REVIEWS DRUG DISCOVERY (2018)
FDA Approval Summary: Tocilizumab for Treatment of Chimeric Antigen Receptor T Cell-Induced Severe or Life-Threatening Cytokine Release Syndrome
Robert Q. Le et al.
ONCOLOGIST (2018)
CAR T cell immunotherapy for human cancer
Carl H. June et al.
SCIENCE (2018)
Clinical and Biological Correlates of Neurotoxicity Associated with CAR T-cell Therapy in Patients with B-cell Acute Lymphoblastic Leukemia
Bianca D. Santomasso et al.
CANCER DISCOVERY (2018)
Enhancing the Potency and Specificity of Engineered T Cells for Cancer Treatment
Sujita Sukumaran et al.
CANCER DISCOVERY (2018)
The development of CAR design for tumor CAR-T cell therapy
Dandan Xu et al.
Oncotarget (2018)
Extracellular NGFR Spacers Allow Efficient Tracking and Enrichment of Fully Functional CAR-T Cells Co-Expressing a Suicide Gene
Monica Casucci et al.
FRONTIERS IN IMMUNOLOGY (2018)
Programming CAR-T cells to kill cancer
Louai Labanieh et al.
NATURE BIOMEDICAL ENGINEERING (2018)
Targeted delivery of a PD-1-blocking scFv by CAR-T cells enhances anti-tumor efficacy in vivo
Sarwish Rafiq et al.
NATURE BIOTECHNOLOGY (2018)
Induction of resistance to chimeric antigen receptor T cell therapy by transduction of a single leukemic B cell
Marco Ruella et al.
NATURE MEDICINE (2018)
Development of a novel target module redirecting UniCAR T cells to Sialyl Tn-expressing tumor cells
L. R. Loureiro et al.
BLOOD CANCER JOURNAL (2018)
Tumor Antigen Escape from CAR T-cell Therapy
Robbie G. Majzner et al.
CANCER DISCOVERY (2018)
Cytokine Release Syndrome with Chimeric Antigen Receptor T Cell Therapy
Noelle Frey et al.
BIOLOGY OF BLOOD AND MARROW TRANSPLANTATION (2018)
Universal CARs, universal T cells, and universal CAR T cells
Juanjuan Zhao et al.
JOURNAL OF HEMATOLOGY & ONCOLOGY (2018)
Switchable control over in vivo CAR T expansion, B cell depletion, and induction of memory
Sophie Viaud et al.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2018)
Making CAR T Cells a Solid Option for Solid Tumors
Andrea Schmidts et al.
FRONTIERS IN IMMUNOLOGY (2018)
Engineering CAR-T Cells for Improved Function Against Solid Tumors
Michael A. Morgan et al.
FRONTIERS IN IMMUNOLOGY (2018)
Preliminary Data on Safety, Cellular Kinetics and Anti-Leukemic Activity of UCART19, an Allogeneic Anti-CD19 CAR T-Cell Product, in a Pool of Adult and Pediatric Patients with High-Risk CD19+Relapsed/Refractory B-Cell Acute Lymphoblastic Leukemia
Reuben Benjamin et al.
BLOOD (2018)
Biomarkers of cytokine release syndrome and neurotoxicity related to CAR-T cell therapy
Zhenguang Wang et al.
BIOMARKER RESEARCH (2018)
Synthetic immune niches for cancer immunotherapy
Jorieke Weiden et al.
NATURE REVIEWS IMMUNOLOGY (2018)
CAR T cells for infection, autoimmunity and allotransplantation
Colby R. Maldini et al.
NATURE REVIEWS IMMUNOLOGY (2018)
CRISPR-Cas9-mediated multiplex gene editing in CAR-T cells
Xiaojuan Liu et al.
CELL RESEARCH (2017)
Enhanced CAR T-cell engineering using non-viral Sleeping Beauty transposition from minicircle vectors
R. Monjezi et al.
LEUKEMIA (2017)
CAR T-cell therapy of solid tumors
Carmen S. M. Yong et al.
IMMUNOLOGY AND CELL BIOLOGY (2017)
New development in CAR-T cell therapy
Zhenguang Wang et al.
JOURNAL OF HEMATOLOGY & ONCOLOGY (2017)
A new insight in chimeric antigen receptor-engineered T cells for cancer immunotherapy
Erhao Zhang et al.
JOURNAL OF HEMATOLOGY & ONCOLOGY (2017)
Integration of a CD19 CAR into the. TCR Alpha Chain Locus Streamlines Production of Allogeneic Gene-Edited CAR T Cells
Daniel T. MacLeod et al.
MOLECULAR THERAPY (2017)
Avoidance of On-Target Off-Tumor Activation Using a Co-stimulation-Only Chimeric Antigen Receptor
Jonathan Fisher et al.
MOLECULAR THERAPY (2017)
Improving Chimeric Antigen Receptor-Modified T Cell Function by Reversing the Immunosuppressive Tumor Microenvironment of Pancreatic Cancer
Somala Mohammed et al.
MOLECULAR THERAPY (2017)
Targeting a CAR to the TRAC locus with CRISPR/Cas9 enhances tumour rejection
Justin Eyquem et al.
NATURE (2017)
CAR T therapies drive into new terrain
Katie Kingwell
NATURE REVIEWS DRUG DISCOVERY (2017)
Development of CAR T cells designed to improve antitumor efficacy and safety
Janneke E. Jaspers et al.
PHARMACOLOGY & THERAPEUTICS (2017)
IN-DEPTH REVIEW: CHIMERIC ANTIGEN RECEPTOR T CELLS-BASED THERAPIES CAR T-cell therapy for lung cancer and malignant pleural mesothelioma
Masha Zeltsman et al.
TRANSLATIONAL RESEARCH (2017)
Endothelial Activation and Blood-Brain Barrier Disruption in Neurotoxicity after Adoptive Immunotherapy with CD19 CAR-T Cells
Juliane Gust et al.
CANCER DISCOVERY (2017)
An oxygen sensitive self-decision making engineered CAR T-cell
Alexandre Juillerat et al.
SCIENTIFIC REPORTS (2017)
Armored CAR T cells enhance antitumor efficacy and overcome the tumor microenvironment
Oladapo O. Yeku et al.
SCIENTIFIC REPORTS (2017)
Increasing the safety and efficacy of chimeric antigen receptor T cell therapy
Hua Li et al.
PROTEIN & CELL (2017)
Current status and perspectives of chimeric antigen receptor modified T cells for cancer treatment
Zhenguang Wang et al.
PROTEIN & CELL (2017)
Global Manufacturing of CAR T Cell Therapy
Bruce L. Levine et al.
MOLECULAR THERAPY-METHODS & CLINICAL DEVELOPMENT (2017)
Current approaches to increase CAR T cell potency in solid tumors: targeting the tumor microenvironment
Irene Scarfo et al.
JOURNAL FOR IMMUNOTHERAPY OF CANCER (2017)
tandem CD19/CD20 CAR lentiviral vector drives on-target and off-target antigen modulation in leukemia cell lines
Dina Schneider et al.
JOURNAL FOR IMMUNOTHERAPY OF CANCER (2017)
Tumor Lysis Syndrome in Patients with Hematological Malignancies
Yohannes Belay et al.
JOURNAL OF ONCOLOGY (2017)
Kinetics and biomarkers of severe cytokine release syndrome after CD19 chimeric antigen receptor-modified T-cell therapy
Kevin A. Hay et al.
BLOOD (2017)
IL-4 blockade alters the tumor microenvironment and augments the response to cancer immunotherapy in a mouse model
Shuku-ei Ito et al.
CANCER IMMUNOLOGY IMMUNOTHERAPY (2017)
Clinical development of CAR T cells-challenges and opportunities in translating innovative treatment concepts
Jessica Hartmann et al.
EMBO MOLECULAR MEDICINE (2017)
Distinct Signaling of Coreceptors Regulates Specific Metabolism Pathways and Impacts Memory Development in CAR T Cells
Omkar U. Kawalekar et al.
IMMUNITY (2016)
Human CAR T cells with cell-intrinsic PD-1 checkpoint blockade resist tumor-mediated inhibition
Leonid Cherkassky et al.
JOURNAL OF CLINICAL INVESTIGATION (2016)
Dual CD19 and CD123 targeting prevents antigen-loss relapses after CD19-directed immunotherapies
Marco Ruella et al.
JOURNAL OF CLINICAL INVESTIGATION (2016)
In vivo genome editing via CRISPR/Cas9 mediated homology-independent targeted integration
Keiichiro Suzuki et al.
NATURE (2016)
Versatile strategy for controlling the specificity and activity of engineered T cells
Jennifer S. Y. Ma et al.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2016)
Switch-mediated activation and retargeting of CAR-T cells for B-cell malignancies
David T. Rodgers et al.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2016)
Chimeric antigen receptor-redirected T cells return to the bench
Claudia Geldres et al.
SEMINARS IN IMMUNOLOGY (2016)
Medical management of side effects related to CAR T cell therapy in hematologic malignancies
Manjusha Namuduri et al.
EXPERT REVIEW OF HEMATOLOGY (2016)
Identification of Predictive Biomarkers for Cytokine Release Syndrome after Chimeric Antigen Receptor T-cell Therapy for Acute Lymphoblastic Leukemia
David T. Teachey et al.
CANCER DISCOVERY (2016)
Chimeric antigen receptor T cells secreting anti-PD-L1 antibodies more effectively regress renal cell carcinoma in a humanized mouse model
Eloah Rabello Suarez et al.
ONCOTARGET (2016)
CAR T Cell Therapy: A Game Changer in Cancer Treatment
Hilde Almasbak et al.
JOURNAL OF IMMUNOLOGY RESEARCH (2016)
CAR models: next-generation CAR modifications for enhanced T-cell function
Daniel Abate-Daga et al.
MOLECULAR THERAPY-ONCOLYTICS (2016)
Toxicity and management in CAR T-cell therapy
Challice L. Bonifant et al.
MOLECULAR THERAPY-ONCOLYTICS (2016)
Different Subsets of T Cells, Memory, Effector Functions, and CAR-T Immunotherapy
Vita Golubovskaya et al.
CANCERS (2016)
Multiplex Genome-Edited T-cell Manufacturing Platform for Off-the-Shelf Adoptive T-cell Immunotherapies
Laurent Poirot et al.
CANCER RESEARCH (2015)
Human Epidermal Growth Factor Receptor 2 (HER2) -Specific Chimeric Antigen Receptor-Modified T Cells for the Immunotherapy of HER2-Positive Sarcoma
Nabil Ahmed et al.
JOURNAL OF CLINICAL ONCOLOGY (2015)
Redesigned Escherichia coli cytosine deaminase: a new facet of suicide gene therapy
Asif Raza et al.
JOURNAL OF GENE MEDICINE (2015)
Engineering CAR-T cells: Design concepts
Shivani Srivastava et al.
TRENDS IN IMMUNOLOGY (2015)
Retargeted human avidin-CAR T cells for adoptive immunotherapy of EGFRvIII expressing gliomas and their evaluation via optical imaging
Kaiyu Liu et al.
ONCOTARGET (2015)
Patient-derived glioblastoma stem cells are killed by CD133-specific CAR T cells but induce the T cell aging marker CD57
Xuekai Zhu et al.
ONCOTARGET (2015)
Biomarkers Accurately Predict Cytokine Release Syndrome (CRS) after Chimeric Antigen Receptor (CAR) T Cell Therapy for Acute Lymphoblastic Leukemia (ALL)
David T. Teachey et al.
BLOOD (2015)
Addition of Fludarabine to Cyclophosphamide Lymphodepletion Improves In Vivo Expansion of CD19 Chimeric Antigen Receptor-Modified T Cells and Clinical Outcome in Adults with B Cell Acute Lymphoblastic Leukemia
Cameron J. Turtle et al.
BLOOD (2015)
A highly compact epitope-based marker/suicide gene for easier and safer T-cell therapy
Brian Philip et al.
BLOOD (2014)
Cytokine release syndrome in cancer immunotherapy with chimeric antigen receptor engineered T cells
Xiao-Jun Xu et al.
CANCER LETTERS (2014)
LY2875358, a Neutralizing and Internalizing Anti-MET Bivalent Antibody, Inhibits HGF-Dependent and HGF-Independent MET Activation and Tumor Growth
Ling Liu et al.
CLINICAL CANCER RESEARCH (2014)
Phase II Trial of the Anti-CD19 Bispecific T Cell-Engager Blinatumomab Shows Hematologic and Molecular Remissions in Patients With Relapsed or Refractory B-Precursor Acute Lymphoblastic Leukemia
Max S. Topp et al.
JOURNAL OF CLINICAL ONCOLOGY (2014)
Reversal of Tumor Immune Inhibition Using a Chimeric Cytokine Receptor
Ann M. Leen et al.
MOLECULAR THERAPY (2014)
Chimeric Antigen Receptor T Cells for Sustained Remissions in Leukemia
Shannon L. Maude et al.
NEW ENGLAND JOURNAL OF MEDICINE (2014)
Efficacy and Toxicity Management of 19-28z CAR T Cell Therapy in B Cell Acute Lymphoblastic Leukemia
Marco L. Davila et al.
SCIENCE TRANSLATIONAL MEDICINE (2014)
Targeting Fibroblast Activation Protein in Tumor Stroma with Chimeric Antigen Receptor T Cells Can Inhibit Tumor Growth and Augment Host Immunity without Severe Toxicity
Liang-Chuan S. Wang et al.
CANCER IMMUNOLOGY RESEARCH (2014)
The inducible caspase-9 suicide gene system as a safety switch to limit on-target, off-tumor toxicities of chimeric antigen receptor T cells
Tessa Gargett et al.
FRONTIERS IN PHARMACOLOGY (2014)
Anti-CD19 CAR T Cells Administered after Low-Dose Chemotherapy Can Induce Remissions of Chemotherapy-Refractory Diffuse Large B-Cell Lymphoma
James N. Kochenderfer et al.
BLOOD (2014)
Immune targeting of fibroblast activation protein triggers recognition of multipotent bone marrow stromal cells and cachexia
Eric Tran et al.
JOURNAL OF EXPERIMENTAL MEDICINE (2013)
Treatment of Metastatic Renal Cell Carcinoma With CAIX CAR-engineered T cells: Clinical Evaluation and Management of On-target Toxicity
Cor H. J. Lamers et al.
MOLECULAR THERAPY (2013)
Chimeric Antigen Receptor-Modified T Cells for Acute Lymphoid Leukemia
Stephan A. Grupp et al.
NEW ENGLAND JOURNAL OF MEDICINE (2013)
RNA-Guided Human Genome Engineering via Cas9
Prashant Mali et al.
SCIENCE (2013)
PD-1-and CTLA-4-Based Inhibitory Chimeric Antigen Receptors (iCARs) Divert Off-Target Immunotherapy Responses
Victor D. Fedorov et al.
SCIENCE TRANSLATIONAL MEDICINE (2013)
T Cells Expressing Chimeric Antigen Receptors Can Cause Anaphylaxis in Humans
Marcela V. Maus et al.
CANCER IMMUNOLOGY RESEARCH (2013)
Targeting of a Conformationally Exposed, Tumor-Specific Epitope of EGFR as a Strategy for Cancer Therapy
Hui K. Gan et al.
CANCER RESEARCH (2012)
Redirecting Gene-Modified T Cells toward Various Cancer Types Using Tagged Antibodies
Koji Tamada et al.
CLINICAL CANCER RESEARCH (2012)
Comparison of Different Suicide-Gene Strategies for the Safety Improvement of Genetically Manipulated T Cells
Virna Marin et al.
HUMAN GENE THERAPY METHODS (2012)
A transgene-encoded cell surface polypeptide for selection, in vivo tracking, and ablation of engineered cells
Xiuli Wang et al.
BLOOD (2011)
Enhancing the specificity of T-cell cultures for adoptive immunotherapy of cancer
Connie P. M. Duong et al.
IMMUNOTHERAPY (2011)
Prognostic significance of acute renal injury in acute tumor lysis syndrome
Michael Darmon et al.
LEUKEMIA & LYMPHOMA (2010)
Case Report of a Serious Adverse Event Following the Administration of T Cells Transduced With a Chimeric Antigen Receptor Recognizing ERBB2
Richard A. Morgan et al.
MOLECULAR THERAPY (2010)
T lymphocytes coexpressing CCR4 and a chimeric antigen receptor targeting CD30 have improved homing and antitumor activity in a Hodgkin tumor model
Antonio Di Stasi et al.
BLOOD (2009)
CAR Mechanics: Driving T Cells into the MUC of Cancer
John Maher et al.
CANCER RESEARCH (2009)
Retroviral transfer of human CD20 as a suicide gene for adoptive T-cell therapy
Marieke Griffioen et al.
HAEMATOLOGICA-THE HEMATOLOGY JOURNAL (2009)
Redirecting specificity of T-cell Populations for CD19 using the Sleeping beauty system
Harjeet Singh et al.
CANCER RESEARCH (2008)
Rasburicase: future directions in tumor lysis management
Jessica Hochberg et al.
EXPERT OPINION ON BIOLOGICAL THERAPY (2008)
Insertional oncogenesis in 4 patients after retrovirus-mediated gene therapy of SCID-X1
Salima Hacein-Bey-Abina et al.
JOURNAL OF CLINICAL INVESTIGATION (2008)
Transduction with the Antioxidant Enzyme Catalase Protects Human T Cells against Oxidative Stress
Takashi Ando et al.
JOURNAL OF IMMUNOLOGY (2008)
The potential immunogenicity of the TK suicide gene does not prevent full clinical benefit associated with the use of TK-transduced donor lymphocytes in HSCT for hematologic malignancies
Catia Traversari et al.
BLOOD (2007)
Analysis of transgene-specific immune responses that limit the in vivo persistence of adoptively transferred HSV-TK-modified donor T cells after allogeneic hematopoietic cell transplantation
C Berger et al.
BLOOD (2006)
Retroviral vector integration deregulates gene expression but has no consequence on the biology and function of transplanted T cells
A Recchia et al.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2006)
LMO2-associated clonal T cell proliferation in two patients after gene therapy for SCID-X1
S Hacein-Bey-Abina et al.
SCIENCE (2003)
Administration of herpes simplex-thymidine kinase-expressing donor T cells with a T-cell-depleted allogeneic marrow graft
P Tiberghien et al.
BLOOD (2001)