Strategies to overcome the side effects of chimeric antigen receptor T cell therapy

Chimeric antigen receptor (CAR) therapy is a method directing T lymphocytes against antigens on the surface of tumors, increasing target cell elimination. Genetic engineering enhances the capability of immune cells to detect new antigens expressed on cell surfaces. CAR T cell therapy is a significant breakthrough for treating human malignancies; however, different side effects (e.g., cytokine release syndrome) restrict its application. Improving design and using various combined receptors enhance the performance of these cells. This review discusses limitations and risk factors associated with CAR T cell therapy. We also review some alternative approaches for developing the next generation of CAR T cells.

Automated summary

Chimeric antigen receptor (CAR) therapy is a genetic engineering approach that enhances the ability of immune cells to detect and eliminate tumor cells expressing new antigens on their surfaces. However, its application is limited by various side effects. Improving design and using combined receptors can enhance the performance of CAR T cells. This review discusses the limitations and risk factors associated with CAR T cell therapy and explores alternative approaches for developing the next generation of CAR T cells.