期刊
ANNALS OF THE NEW YORK ACADEMY OF SCIENCES
卷 1509, 期 1, 页码 37-49出版社
WILEY
DOI: 10.1111/nyas.14707
关键词
PTSD; brain morphometry; structural MRI; soldiers; disorder duration
资金
- Surgeon General's Health Research Program of the Canadian National Defence and Veterans Affairs Canada
- Brain Canada Foundation
- Canada Research Chair in Cognitive Neuroplasticity
This study found that soldiers with PTSD exhibit brain structural differences compared to healthy individuals, including smaller and thinner frontal regions and larger subcortical structures, which may be related to impaired emotional regulation. These findings provide insights into potential therapeutic approaches for PTSD.
Patients with posttraumatic stress disorder (PTSD) display several structural brain differences when compared with healthy individuals. However, findings are particularly inconsistent for soldiers with PTSD. Here, we characterized the brain morphometry of 37 soldiers from the Canadian Armed Forces with adulthood war-related PTSD using structural magnetic resonance imaging. We assessed time since trauma, as well as PTSD, depressive, and anxiety symptoms with the Modified PTSD Symptoms Scale, Beck Depression Inventory, and Beck Anxiety Inventory, respectively. Whole-brain morphometry was extracted with FreeSurfer and compared with a validated normative database of more than 2700 healthy individuals. Volume and thickness from several regions differed from the norms. Frontal regions were smaller and thinner, particularly the superior and rostral middle frontal gyri. Furthermore, smaller left rostral middle frontal gyrus, left pericalcarine cortex, and right fusiform gyrus were associated with more recent trauma. All subcortical structures were bigger, except the hippocampus. These findings suggest a particular brain morphometric signature of PTSD in soldiers. Smaller and thinner frontal and larger subcortical regions support impaired top-down and/or downregulation of emotional response in PTSD. Finally, the correlation of smaller frontal, temporal, and occipital regions with more recent trauma might inform future therapeutic approaches.
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