期刊
ANIMAL GENETICS
卷 52, 期 6, 页码 887-890出版社
WILEY
DOI: 10.1111/age.13145
关键词
cattle; Prolactin receptor; slick mutation; thermotolerance
资金
- Holstein Association USA, Inc.
- Foundation for Food and Agriculture Research
- USDA Hatch Funds from University of Puerto Rico Agricultural Experiment Station
- L.E. Red Larson Endowment
The study shows that the inheritance of the SLICK1 allele in cattle does not affect the development and maturity of embryos or fetuses. This suggests that the allele does not have a deleterious effect on embryonic or fetal function, as indicated by the frequency of the allele remaining constant in offspring.
The slick-hair phenotype in cattle is due to one of a series of mutations in the prolactin receptor (PRLR) that cause truncation of the C-terminal region of the protein involved in JAK2/STAT5 activation during prolactin signaling. Here we evaluated whether the inheritance of the SLICK1 allele, the first slick mutation discovered, is inherited in a fashion consistent with Hardy-Weinberg equilibrium. It was hypothesized that any deleterious effect of inheriting the allele on embryonic or fetal function would result in reduced frequency of the allele in offspring. A total of 525 Holstein and Senepol cattle produced from matings involving one or both parents with the SLICK1 allele were genotyped. The observed frequency of the SLICK1 allele (0.247) was not significantly different than the expected frequency of 0.269. These results support the idea that inheritance of the SLICK1 allele does not act in the embryo or fetus to modify its competence to complete development to term.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据