期刊
ANIMAL BIOTECHNOLOGY
卷 33, 期 2, 页码 356-361出版社
TAYLOR & FRANCIS INC
DOI: 10.1080/10495398.2021.2003807
关键词
Weaned piglets; ferulic acid; antioxidant capacity; intestinal barrier function
资金
- Sichuan Youth Science and Technology Innovation Research Team Project [2020JDTD0026]
- National Key R&D Program of China [2018YFD0500403]
The study found that dietary supplementation of 0.05% and 0.45% ferulic acid significantly increased intestinal antioxidant capacity and intestinal barrier function in weaned piglets.
This study was conducted to explore the effects of dietary ferulic acid (FA) supplementation on intestinal antioxidant capacity and intestinal barrier function in weaned piglets. Eighteen 21-day-old castrated male DLY (Duroc x Landrace x Yorkshire) weaned piglets were randomly divided into control, 0.05% FA, and 0.45% FA groups, respectively. The experiment lasted for 5 weeks. The results showed that dietary 0.05 and 0.45% FA supplementation significantly increased catalase activity (p < 0.001), the protein levels of nuclear factor E2-related factor 2 (Nrf2) and NAD(P)H quinone dehydrogenase 1 (p < 0.05), and the mRNA levels of superoxide dismutase 1, glutathione reductase and Nrf2 (p < 0.05) in jejunum when compared with the control group. Dietary 0.05% FA supplementation also increased the mRNA level of glutathione S-transferase (p < 0.05) in jejunum. Meanwhile, Dietary 0.05 and 0.45% FA supplementation significantly increased the protein expression of zonula occludens 1 (ZO-1) (p < 0.05), and dietary supplementation of 0.05% FA increased the mRNA levels of ZO-1, zonula occludens 2, mucin 1, mucin 2, occluding, and claudin-1 (p < 0.05) in jejunum. Together, our data suggest that dietary 0.05% FA supplementation improves the intestinal antioxidant capacity and intestinal barrier function of weaned piglets.
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