期刊
ANIMAL BIOTECHNOLOGY
卷 -, 期 -, 页码 -出版社
TAYLOR & FRANCIS INC
DOI: 10.1080/10495398.2021.1980400
关键词
BMPRIB; litter size; sheep; SNPs; allele distribution
资金
- Research and Demonstration on Nutrition Balance of Grazing Cattle and Sheep special scientific research project of public welfare industry (Agriculture) [201303062]
- Gansu Agricultural University Fund Project [GSAU-ZL-2015-027]
- Chinese National Natural Science Foundation [31260547]
The study identified two single nucleotide polymorphisms, rs427897187 G > A and rs403555643 A > G, in the BMPRIB gene which could serve as potential molecular markers for improving the reproductive performance of Chinese indigenous sheep. These markers offer a new direction for breeding programs focusing on increasing litter size in indigenous sheep populations.
The BMPRIB gene belongs to the TGF-beta superfamily and is considered to be a regulator of sheep reproductive performance. Single nucleotide polymorphisms (SNPs) of BMPRIB gene in the Small Tail Han, Hu, Mongolian, Oula, Gansu Alpine Fine-wool, Dorper and Australian White sheep were detected by Sanger sequencing. Five SNPs (rs427897187 G > A, rs418841713 A > G, rs159952533 T > C, rs429416173 C > A and rs403555643 A > G) of BMPRIB gene were identified. For rs427897187 G > A, further analysis revealed that genotype GG and GA had 0.26 (p < 0.05) and 0.33 (p < 0.05) litter size less than those with genotype AA in Oula sheep. For rs403555643 A > G, further analysis revealed that genotype GG and AG had 0.65 (p < 0.05) and 0.38 (p < 0.05) litter size more than those with genotype AA in Oula sheep, and genotype GG had 0.56 (p < 0.05) litter size more than those with genotype AA in Mongolian sheep. The results showed that rs427897187 G > A and rs403555643 A > G are potential molecular markers wich could improve litter size of Chinese indigenous sheep and be used in Chinese indigenous sheep breeding.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据