期刊
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION
卷 61, 期 20, 页码 -出版社
WILEY-V C H VERLAG GMBH
DOI: 10.1002/anie.202117843
关键词
2,2 '-Bipyridine Ligands; Asymmetric Catalysis; Diaryl Carbinols; Enantioselectivity; Reductive Additions
资金
- NSFC [22171218, 21971202]
- Shaanxi Provincial Science and Technology Department [2020JC-08]
A new class of chiral bipyridine ligands, SBpy, featuring minimized steric hindrance and structural tunability, was designed and developed for the highly enantioselective Ni-catalyzed addition reaction. Compared to known methods, this reaction is more cost-effective and tolerant towards functional groups. The proposed reaction mechanism and stereocontrol model were based on experimental and computational results.
A new class of chiral 2,2'-bipyridine ligands, SBpy, featuring minimized short-range steric hindrance and structural tunability was rationally designed and developed, and the effectiveness was demonstrated in the first highly enantioselective Ni-catalyzed addition of aryl halides to aldehydes. In comparison with known approaches using preformed aryl metallic reagents, this reaction is more step-economical and functional group tolerant. The reaction mechanism and a model of stereocontrol were proposed based on experimental and computational results.
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