4.8 Article

Functional Characterization and Protein Engineering of a Triterpene 3-/6-/2′-O-Glycosyltransferase Reveal a Conserved Residue Critical for the Regiospecificity

相关参考文献

注意:仅列出部分参考文献,下载原文获取全部文献信息。
Review Chemistry, Medicinal

Phytochemistry and cardiovascular protective effects of Huang-Qi (Astragali Radix)

Hui-fei Su et al.

Summary: Huang-Qi, an herbal tonic derived from the roots of Astragalus membranaceus and A. membranaceus var. mongholicus, is widely used in China and other countries for cardiovascular protection. This review comprehensively discusses the chemical differences between the two species, pharmacological activities, and mechanisms of action of Huang-Qi and its bioactive compounds in treating cardiovascular diseases, citing 171 references from February 1983 to March 2020.

MEDICINAL RESEARCH REVIEWS (2021)

Article Medicine, Research & Experimental

Astragaloside IV-targeting miRNA-1 attenuates lipopolysaccharide-induced cardiac dysfunction in rats through inhibition of apoptosis and autophagy

Qiuning Wang et al.

Summary: This study demonstrated that AS-IV protects against LPS-induced cardiac dysfunction by inhibiting calcium-mediated apoptosis and autophagy by targeting miR-1, providing a new mechanism for the therapeutic effect of AS-IV on cardiac dysfunction.

LIFE SCIENCES (2021)

Article Chemistry, Multidisciplinary

Functional Characterization and Structural Basis of an Efficient Di-C-glycosyltransferase from Glycyrrhiza glabra

Meng Zhang et al.

JOURNAL OF THE AMERICAN CHEMICAL SOCIETY (2020)

Article Biochemical Research Methods

Crown-ether-mediated crystal structures of the glycosyltransferase PaGT3 from Phytolacca americana

Rakesh Maharjan et al.

ACTA CRYSTALLOGRAPHICA SECTION D-STRUCTURAL BIOLOGY (2020)

Article Chemistry, Physical

Catalytic Mechanism of Human Aldehyde Oxidase

Pedro Ferreira et al.

ACS CATALYSIS (2020)

Review Biotechnology & Applied Microbiology

Triterpenoid-biosynthetic UDP-glycosyltransferases from plants

Shadi Rahimi et al.

BIOTECHNOLOGY ADVANCES (2019)

Article Chemistry, Multidisciplinary

Molecular and Structural Characterization of a Promiscuous C-Glycosyltransferase from Trollius chinensis

Jun-Bin He et al.

ANGEWANDTE CHEMIE-INTERNATIONAL EDITION (2019)

Article Multidisciplinary Sciences

A noncanonical vacuolar sugar transferase required for biosynthesis of antimicrobial defense compounds in oat

Anastasia Orme et al.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2019)

Article Biochemistry & Molecular Biology

SWISS-MODEL: homology modelling of protein structures and complexes

Andrew Waterhouse et al.

NUCLEIC ACIDS RESEARCH (2018)

Article Biochemistry & Molecular Biology

The SWISS-MODEL Repository-new features and functionality

Stefan Bienert et al.

NUCLEIC ACIDS RESEARCH (2017)

Article Biotechnology & Applied Microbiology

Biosynthesis of plant-derived ginsenoside Rh2 in yeast via repurposing a key promiscuous microbial enzyme

Yu Zhuang et al.

METABOLIC ENGINEERING (2017)

Article Multidisciplinary Sciences

The biosynthetic pathway of the nonsugar, high-intensity sweetener mogroside V from Siraitia grosvenorii

Maxim Itkin et al.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2016)

Article Chemistry, Multidisciplinary

Probing the Catalytic Promiscuity of a Regio- and Stereospecific C-Glycosyltransferase from Mangifera indica

Dawei Chen et al.

ANGEWANDTE CHEMIE-INTERNATIONAL EDITION (2015)

Article Biotechnology & Applied Microbiology

Production of bioactive ginsenosides Rh2 and Rg3 by metabolically engineered yeasts

Pingping Wang et al.

METABOLIC ENGINEERING (2015)

Article Biochemistry & Molecular Biology

Identification of the glucosyltransferase that mediates direct flavone C-glucosylation in Gentiana triflora

Nobuhiro Sasaki et al.

FEBS LETTERS (2015)

Review Plant Sciences

Triterpene Biosynthesis in Plants

Ramesha Thimmappa et al.

ANNUAL REVIEW OF PLANT BIOLOGY, VOL 65 (2014)

Review Biotechnology & Applied Microbiology

Advances in the biotechnological glycosylation of valuable flavonoids

Jianbo Xiao et al.

BIOTECHNOLOGY ADVANCES (2014)

Article Chemistry, Multidisciplinary

Switching between O- and C-Glycosyltransferase through Exchange of Active-Site Motifs

Alexander Gutmann et al.

ANGEWANDTE CHEMIE-INTERNATIONAL EDITION (2012)

Article Biochemical Research Methods

Toward the estimation of the absolute quality of individual protein structure models

Pascal Benkert et al.

BIOINFORMATICS (2011)

Review Biochemistry & Molecular Biology

Molecular activities, biosynthesis and evolution of triterpenoid saponins

Jorg M. Augustin et al.

PHYTOCHEMISTRY (2011)

Article Chemistry, Multidisciplinary

Computational enzymology

Richard Lonsdale et al.

CHEMICAL COMMUNICATIONS (2010)

Review Chemistry, Multidisciplinary

QM/MM Methods for Biomolecular Systems

Hans Martin Senn et al.

ANGEWANDTE CHEMIE-INTERNATIONAL EDITION (2009)

Review Biochemistry & Molecular Biology

Structure, mechanism and engineering of plant natural product glycosyltransferases

Xiaoqiang Wang

FEBS LETTERS (2009)

Article Biochemistry & Molecular Biology

The C-Glycosylation of Flavonoids in Cereals

Melissa Brazier-Hicks et al.

JOURNAL OF BIOLOGICAL CHEMISTRY (2009)

Article Multidisciplinary Sciences

Characterization and engineering of the bifunctional N- and O-glucosyltransferase involved in xenobiotic metabolism in plants

Melissa Brazier-Hicks et al.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2007)

Article Biochemistry & Molecular Biology

Molecular modeling insights into the catalytic mechanism of the retaining galactosyltransferase LgtC

I Tvaroska

CARBOHYDRATE RESEARCH (2004)