Reversible Supramolecular Polymorphism in Solution and Solid Matrix by Manipulating Sidegroup Conformation

Reversible switching between supramolecular polymorphs offers a great way to introduce stimuli-responsiveness. Supramolecular polymorphism is usually achieved through pathway complexity, or by exploiting solvent-solute interactions. But, steering a self-assembly along a specific pathway to form a kinetically-stable aggregate is not easy. Also, changing solvent to switch between polymorphs is impractical. We present a perylene bisimide molecule with a trans-azobenzene sidegroup that assembles into three supramolecular polymorphs with distinct colors, morphologies, packing and aggregation mechanism. Optical absorption and FTIR spectroscopy reveal the importance of hydrogen-bonding interaction between protic solvent and azo N that controls the planarity of the azobenzene group and influences molecular packing. This interaction can be further modulated using temperature, and solution pH to reversibly switch between the three polymorphs, in solution as well as in solid silica-gel matrix.

Automated summary

This study presents a perylene bisimide molecule with a trans-azobenzene sidegroup that can assemble into three distinct supramolecular polymorphs in both solution and solid state. The results reveal the significance of hydrogen-bonding interaction between protic solvent and azo N in controlling the formation and switching of polymorphs.