Fighting Antibiotic-Resistant Bacteria: Promising Strategies Orchestrated by Molecularly Imprinted Polymers

Infections caused by antibiotic-resistant bacteria are difficult and sometimes impossible to treat, making them one of the major public health problems of our time. We highlight how one unique material, molecularly imprinted polymers (MIPs), can orchestrate several strategies to fight this serious societal issue. MIPs are tailor-made biomimetic supramolecular receptors that recognize and bind target molecules with high affinity and selectivity, comparable to those of antibodies. While research on MIPs for combatting cancer has flourished, comprehensive work on their involvement in combatting resistant superbugs has been rather scarce. This review aims at filling this gap. We will describe the causes of bacterial resistance and at which level MIPs can deploy their weapons. MIPs' targets can be biofilm constituents, quorum sensing messengers, bacterial surface proteins and antibiotic-deactivating enzymes, among others. We will conclude with the current challenges and future developments in this field.

Automated summary

Infections caused by antibiotic-resistant bacteria are a major public health problem. Molecularly imprinted polymers (MIPs) offer a promising solution by recognizing and binding target molecules with high affinity and selectivity, similar to antibodies. This review aims to explore the potential of MIPs in combating resistant superbugs, filling a gap in current research.