期刊
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION
卷 60, 期 50, 页码 26368-26372出版社
WILEY-V C H VERLAG GMBH
DOI: 10.1002/anie.202111382
关键词
carbon quaternary stereocenters; copper-catalyzed carbomagnesiation; directing group; regioselectivity
资金
- Israel Science Foundation [330/17]
A regio- and diastereoselective copper-catalyzed carbomagnesiation of 1,2-dialkylated cyclopropenes is reported, with regioselectivity controlled by a subtle tethered Lewis basic moiety. Chelating moieties allow differentiation between two electronically equivalent organometallic intermediates, and further functionalization provides access to polysubstituted stereodefined cyclopropanes with up to five alkyl groups.
A regio- and diastereoselective copper-catalyzed carbomagnesiation of 1,2-dialkylated cyclopropenes is reported. The regioselectivity is controlled by a subtle tethered Lewis basic moiety. The chelating moieties allow the differentiation between two electronically tantamount organometallic intermediates. Further functionalization grants access to polysubstituted stereodefined cyclopropanes bearing up to five alkyl groups.
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