期刊
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION
卷 61, 期 20, 页码 -出版社
WILEY-V C H VERLAG GMBH
DOI: 10.1002/anie.202200072
关键词
Imaging; Nanoparticles; SERS; Widefield Microscopy
资金
- Ministry of Science, Innovation, and Universities [PDC2021-121787-I00, MCIU: RTI2018099957-J-I00]
- European Commission (ERC) [670949-LightNet]
- Catalan AGAUR [2017SGR883, 2017SGR1369]
- Fundacio Privada Cellex
- Fundacio Privada Mir-Puig
- Generalitat de Catalunya through the CER-CA program
- MCIN/AEI [CEX2019-000910-S]
- Ministry of Science, Innovation, and Universities/AEI [PID2020-120306RB-I00]
- Ministry of Science, Innovation, and Universities/European Union Next Generation/PRTR [PDC2021-121787-I00]
- Universitat Rovira i Virgili [2021PFR-URV-B2-02]
Large-scale SERS particle screening (LSSPS) is a fast multiplexed widefield screening approach that quantifies both Raman and Rayleigh scattering simultaneously, allowing for direct quantification of the fraction of SERS-active particles and unprecedented correlation of SERS activity with particle size.
Surface-enhanced Raman scattering (SERS) imaging is a powerful technology with unprecedent potential for ultrasensitive chemical analysis. Point-by-point scanning and often excessively long spectral acquisition-times hamper the broad exploitation of the full analytical potential of SERS. Here, we introduce large-scale SERS particle screening (LSSPS), a multiplexed widefield screening approach to particle characterization, which is 500-1000 times faster than typical confocal Raman implementations. Beyond its higher throughput, LSSPS simultaneously quantifies both the sample's Raman and Rayleigh scattering to directly quantify the fraction of SERS-active particles which allows for an unprecedented correlation of SERS activity with particle size..
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