期刊
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION
卷 61, 期 15, 页码 -出版社
WILEY-V C H VERLAG GMBH
DOI: 10.1002/anie.202111266
关键词
chemical protein synthesis; lipidated protein; lipopeptides; post-translational modification; semisynthesis
资金
- Australian Research Council Centre of Excellence for Innovations in Peptide and Proteins Science, a Research Training Program PhD Scholarship [CE200100012]
- Austrian Science Fund (FWF-Project) [P29458]
- Austrian Science Fund (FWF) [P29458] Funding Source: Austrian Science Fund (FWF)
Lipidation is a common modification of peptides and proteins that can affect crucial biological activities. The use of synthetic techniques allows for the preparation of pure and homogeneously modified lipidated proteins, revealing the impact of these modifications on protein structure and function.
Lipidation is a ubiquitous modification of peptides and proteins that can occur either co- or post-translationally. An array of different lipid classes can adorn proteins and has been shown to influence a number of crucial biological activities, including the regulation of signaling, cell-cell adhesion events, and the anchoring of proteins to lipid rafts and phospholipid membranes. Whereas nature employs a range of enzymes to install lipid modifications onto proteins, the use of these for the chemoenzymatic generation of lipidated proteins is often inefficient or impractical. An alternative is to harness the power of modern synthetic and semisynthetic technologies to access lipid-modified proteins in a pure and homogeneously modified form. This Review aims to highlight significant advances in the development of lipidation and ligation chemistry and their implementation in the synthesis and semisynthesis of homogeneous lipidated proteins that have enabled the influence of these modifications on protein structure and function to be uncovered.
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