期刊
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION
卷 61, 期 4, 页码 -出版社
WILEY-V C H VERLAG GMBH
DOI: 10.1002/anie.202113089
关键词
Acrylates; Allyl alcohols; alpha-Oxygenated Z-olefins; Ruthenium; Z-selective olefin-metathesis
资金
- Umicore
The article describes an efficient Z-selective metathesis of various terminal acrylates and allyl alcohols, enabling the construction of high value-added α-oxygenated Z-olefins from readily available feedstock chemicals. These challenging metathesis transformations are achieved by novel cyclometalated Ru-carbene-nitrate complexes with bulky-yet-flexible side arms, unlocked by new organometallic syntheses.
alpha-Oxygenated Z-olefins are ubiquitous in biologically active molecules and serve as versatile handles for organic synthesis, but their syntheses are often tedious and less selective. Here we report the efficient Z-selective metathesis of various terminal acrylates and allyl alcohols, which enables facile and selective construction of high value-added a-oxygenated Z-olefins from readily available feedstock chemicals. These challenging metathesis transformations are enabled by novel cyclometalated Ru-carbene-nitrate complexes bearing bulky-yet-flexible side arms, whose assembly was unlocked by new organometallic syntheses.
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