4.8 Article

Sink/Float Magnetic Immunoassays for In-Field Bioassays

期刊

ANGEWANDTE CHEMIE-INTERNATIONAL EDITION
卷 60, 期 52, 页码 26947-26953

出版社

WILEY-V C H VERLAG GMBH
DOI: 10.1002/anie.202108714

关键词

density-based assays; magnetic immunoassays; sink; float magnetic immunoassays; sink; float tests

资金

  1. University of Massachusetts Lowell through start-up funds
  2. Tripathy Memorial Graduate Fellowship Award (University of Massachusetts Lowell)
  3. Graduate Research Grant Award (Graduate Student Association, University of Massachusetts Lowell)

向作者/读者索取更多资源

This study presents a new type of sink/float magnetic immunoassays for the rapid detection of biomarkers in untreated biological samples, which are simple to operate and may meet regulatory authorities' criteria for field use.
Analytical tests/devices that are used outside laboratory settings are required to have a very simple analytical protocol to get clearance by regulatory authorities. This study describes sink/float magnetic immunoassays, a new type of rapid, mix-and-observe, instrument-free tests for the detection of biomarkers in untreated biological samples that are very simple and might meet the simple-to-use criterion of authorities to be used in the field. These tests can tell whether an analyte is above or below a predetermined level within 25-45 minutes based on the sinking or floating of a mm-sized sphere on the surface of which an immunoassay that uses reporter antibodies conjugated to superparamagnetic nanoparticles is performed. This manuscript describes the theory and proof-of-concept applications of sink/float magnetic immunoassays for the detection of C-Reactive Protein, anti-Treponema pallidum antibodies and E. coli bacteria.

作者

我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。

评论

主要评分

4.8
评分不足

次要评分

新颖性
-
重要性
-
科学严谨性
-
评价这篇论文

推荐

暂无数据
暂无数据