4.8 Article

Catalytic Asymmetric Homologation of 4-Substituted Cyclohexanones with CF3CHN2: Enantioselective Synthesis of α-Trifluoromethyl Cycloheptanones

相关参考文献

注意:仅列出部分参考文献,下载原文获取全部文献信息。
Article Chemistry, Multidisciplinary

Catalytic Asymmetric Homologation of Ketones with α-Alkyl α-Diazo Esters

Fei Tan et al.

Summary: This study describes an enantioselective homologation of ketones with alpha-alkyl alpha-diazo esters using a chiral scandium(III) N,N'-dioxide catalyst to produce a series of optically active beta-keto esters with an all-carbon quaternary center. This method provides a highly selective and synthetically efficient strategy for the synthesis of enantioenriched compounds.

JOURNAL OF THE AMERICAN CHEMICAL SOCIETY (2021)

Article Chemistry, Multidisciplinary

Catalytic Enantioselective Dehydrogenative Si-O Coupling to Access Chiroptical Silicon-Stereogenic Siloxanes and Alkoxysilanes

Jiefeng Zhu et al.

Summary: A rhodium-catalyzed enantioselective construction of triorgano-substituted silicon-stereogenic siloxanes and alkoxysilanes has been developed, expanding the chemical space of silicon-centered chiral molecules. The method was further demonstrated by constructing CPL-active silicon-stereogenic alkoxysilane small organic molecules with potential applications in chiral organic optoelectronic materials.

JOURNAL OF THE AMERICAN CHEMICAL SOCIETY (2021)

Article Chemistry, Multidisciplinary

Asymmetric Synthesis of Silicon-Stereogenic Silanes by Copper-Catalyzed Desymmetrizing Protoboration of Vinylsilanes

Ge Zhang et al.

ANGEWANDTE CHEMIE-INTERNATIONAL EDITION (2020)

Review Chemistry, Multidisciplinary

2,2,2-Trifluorodiazoethane (CF3CHN2): A Long Journey since 1943

Pavel K. Mykhailiuk

CHEMICAL REVIEWS (2020)

Article Chemistry, Multidisciplinary

Organocatalytic Synthesis of α-Trifluoromethyl Allylboronic Acids by Enantioselective 1,2-Borotropic Migration

Sybrand J. T. Jonker et al.

JOURNAL OF THE AMERICAN CHEMICAL SOCIETY (2020)

Article Chemistry, Multidisciplinary

Taming Radical Intermediates for the Construction of Enantioenriched Trifluoromethylated Quaternary Carbon Centers

Roxan Calvo et al.

ANGEWANDTE CHEMIE-INTERNATIONAL EDITION (2019)

Review Chemistry, Multidisciplinary

Homologation Reaction of Ketones with Diazo Compounds

Nuno R. Candeias et al.

CHEMICAL REVIEWS (2016)

Article Chemistry, Organic

Three-component synthesis of C2F5-substituted pyrazoles from C2F5CH2NH2•HCl, NaNO2 and electron-deficient alkynes

Pavel K. Mykhailiuk

BEILSTEIN JOURNAL OF ORGANIC CHEMISTRY (2015)

Article Chemistry, Multidisciplinary

Catalytic Asymmetric Synthesis of Enantioenriched Heterocycles Bearing a CCF3 Stereogenic Center

Yi-Yong Huang et al.

CHEMISTRY-A EUROPEAN JOURNAL (2015)

Article Chemistry, Medicinal

Applications of Fluorine in Medicinal Chemistry

Eric P. Gillis et al.

JOURNAL OF MEDICINAL CHEMISTRY (2015)

Article Chemistry, Multidisciplinary

Photo-organocatalytic Enantioselective Perfluoroalkylation of β-Ketoesters

Lukasz Wozniak et al.

JOURNAL OF THE AMERICAN CHEMICAL SOCIETY (2015)

Article Chemistry, Multidisciplinary

Catalytic Asymmetric Intramolecular Homologation of Ketones with α-Diazoesters: Synthesis of Cyclic α-Aryl/Alkyl β-Ketoesters

Wei Li et al.

ANGEWANDTE CHEMIE-INTERNATIONAL EDITION (2015)

Article Chemistry, Multidisciplinary

Generation of C2F5CHN2 In Situ and Its First Reaction: [3+2] Cycloaddition with Alkenes

Pavel K. Mykhailiuk

CHEMISTRY-A EUROPEAN JOURNAL (2014)

Article Chemistry, Multidisciplinary

Enantioselective Synthesis of α-Alkyl-β-ketoesters: Asymmetric Roskamp Reaction Catalyzed by an Oxazaborolidinium Ion

Lizhu Gao et al.

ANGEWANDTE CHEMIE-INTERNATIONAL EDITION (2012)

Article Chemistry, Multidisciplinary

Highly Enantioselective Copper-Catalyzed Electrophilic Trifluoromethylation of β-Ketoesters

Qing-Hai Deng et al.

JOURNAL OF THE AMERICAN CHEMICAL SOCIETY (2012)

Article Chemistry, Multidisciplinary

Synthesis of Trifluoroethyl-Substituted Ketones from Aldehydes and Cyclohexanones

Bill Morandi et al.

ANGEWANDTE CHEMIE-INTERNATIONAL EDITION (2011)

Review Chemistry, Multidisciplinary

Organic fluorine compounds: a great opportunity for enhanced materials properties

Ricarda Berger et al.

CHEMICAL SOCIETY REVIEWS (2011)

Article Chemistry, Multidisciplinary

Desymmetrizing Asymmetric Ring Expansion of Cyclohexanones with α-Diazoacetates Catalyzed by Chiral Aluminum Lewis Acid

Takuya Hashimoto et al.

JOURNAL OF THE AMERICAN CHEMICAL SOCIETY (2011)

Article Chemistry, Organic

An Enantioselective Synthesis of 2-Aryl Cycloalkanones by Sc-Catalyzed Carbon Insertion

Victor L. Rendina et al.

ORGANIC LETTERS (2011)

Article Chemistry, Multidisciplinary

Enantioselective α-Trifluoromethylation of Aldehydes via Photoredox Organocatalysis

David A. Nagib et al.

JOURNAL OF THE AMERICAN CHEMICAL SOCIETY (2009)

Review Chemistry, Multidisciplinary

Fluorine in medicinal chemistry

Sophie Purser et al.

CHEMICAL SOCIETY REVIEWS (2008)

Review Multidisciplinary Sciences

Fluorine in pharmaceuticals:: Looking beyond intuition

Klaus Mueller et al.

SCIENCE (2007)